Clinical usefulness of biochemical monitoring in colorectal cancer

M. Plebani, G. Delle Fave, R. Fiocca, A. Saggioro, V. Savarino, V. Stanghellini

Research output: Contribution to journalArticle

Abstract

Although the great part of patients with colorectal cancer undergoes curative surgery, 50% of them eventually die of the disease. Early detection of recurrences must then be regarded as a major effort in order to improve post surgical survival. Recently, the determination of tumor markers with the aim of obtaining earlier detection of recurrences and reliable information that may guide the decision whether performing second look surgery has been proposed in clinical protocols as a complementary tool to clinical and instrumental investigations. Despite the quite promising data on the value of increased serum levels of some tumor markers, mainly the carcinoembryonic antigen (CEA), tissue polypeptide antigen (TPA) and CA 19-9, in predicting tumor reappearance, the real gain in terms of survival remains to be defined. This article reviews the current available data on the clinical role and the usefulness of biochemical monitoring in this tumor type, identifying and discussing the key issues of a rational approach for the use of tumor markers in colorectal cancer patient follow-up programs.

Original languageEnglish
Pages (from-to)112-116
Number of pages5
JournalEuropean Journal of Laboratory Medicine
Volume4
Issue number2
Publication statusPublished - 1996

Fingerprint

Tumor Biomarkers
Colorectal Neoplasms
Second-Look Surgery
Tissue Polypeptide Antigen
Recurrence
Survival
Carcinoembryonic Antigen
Clinical Protocols
Neoplasms
Serum

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Plebani, M., Delle Fave, G., Fiocca, R., Saggioro, A., Savarino, V., & Stanghellini, V. (1996). Clinical usefulness of biochemical monitoring in colorectal cancer. European Journal of Laboratory Medicine, 4(2), 112-116.

Clinical usefulness of biochemical monitoring in colorectal cancer. / Plebani, M.; Delle Fave, G.; Fiocca, R.; Saggioro, A.; Savarino, V.; Stanghellini, V.

In: European Journal of Laboratory Medicine, Vol. 4, No. 2, 1996, p. 112-116.

Research output: Contribution to journalArticle

Plebani, M, Delle Fave, G, Fiocca, R, Saggioro, A, Savarino, V & Stanghellini, V 1996, 'Clinical usefulness of biochemical monitoring in colorectal cancer', European Journal of Laboratory Medicine, vol. 4, no. 2, pp. 112-116.
Plebani M, Delle Fave G, Fiocca R, Saggioro A, Savarino V, Stanghellini V. Clinical usefulness of biochemical monitoring in colorectal cancer. European Journal of Laboratory Medicine. 1996;4(2):112-116.
Plebani, M. ; Delle Fave, G. ; Fiocca, R. ; Saggioro, A. ; Savarino, V. ; Stanghellini, V. / Clinical usefulness of biochemical monitoring in colorectal cancer. In: European Journal of Laboratory Medicine. 1996 ; Vol. 4, No. 2. pp. 112-116.
@article{066952cf313f4442a8de721b3edbe040,
title = "Clinical usefulness of biochemical monitoring in colorectal cancer",
abstract = "Although the great part of patients with colorectal cancer undergoes curative surgery, 50{\%} of them eventually die of the disease. Early detection of recurrences must then be regarded as a major effort in order to improve post surgical survival. Recently, the determination of tumor markers with the aim of obtaining earlier detection of recurrences and reliable information that may guide the decision whether performing second look surgery has been proposed in clinical protocols as a complementary tool to clinical and instrumental investigations. Despite the quite promising data on the value of increased serum levels of some tumor markers, mainly the carcinoembryonic antigen (CEA), tissue polypeptide antigen (TPA) and CA 19-9, in predicting tumor reappearance, the real gain in terms of survival remains to be defined. This article reviews the current available data on the clinical role and the usefulness of biochemical monitoring in this tumor type, identifying and discussing the key issues of a rational approach for the use of tumor markers in colorectal cancer patient follow-up programs.",
author = "M. Plebani and {Delle Fave}, G. and R. Fiocca and A. Saggioro and V. Savarino and V. Stanghellini",
year = "1996",
language = "English",
volume = "4",
pages = "112--116",
journal = "European Journal of Laboratory Medicine",
issn = "1122-8652",
publisher = "SIMeL Societa Italiana di Medicina di Laboratorio",
number = "2",

}

TY - JOUR

T1 - Clinical usefulness of biochemical monitoring in colorectal cancer

AU - Plebani, M.

AU - Delle Fave, G.

AU - Fiocca, R.

AU - Saggioro, A.

AU - Savarino, V.

AU - Stanghellini, V.

PY - 1996

Y1 - 1996

N2 - Although the great part of patients with colorectal cancer undergoes curative surgery, 50% of them eventually die of the disease. Early detection of recurrences must then be regarded as a major effort in order to improve post surgical survival. Recently, the determination of tumor markers with the aim of obtaining earlier detection of recurrences and reliable information that may guide the decision whether performing second look surgery has been proposed in clinical protocols as a complementary tool to clinical and instrumental investigations. Despite the quite promising data on the value of increased serum levels of some tumor markers, mainly the carcinoembryonic antigen (CEA), tissue polypeptide antigen (TPA) and CA 19-9, in predicting tumor reappearance, the real gain in terms of survival remains to be defined. This article reviews the current available data on the clinical role and the usefulness of biochemical monitoring in this tumor type, identifying and discussing the key issues of a rational approach for the use of tumor markers in colorectal cancer patient follow-up programs.

AB - Although the great part of patients with colorectal cancer undergoes curative surgery, 50% of them eventually die of the disease. Early detection of recurrences must then be regarded as a major effort in order to improve post surgical survival. Recently, the determination of tumor markers with the aim of obtaining earlier detection of recurrences and reliable information that may guide the decision whether performing second look surgery has been proposed in clinical protocols as a complementary tool to clinical and instrumental investigations. Despite the quite promising data on the value of increased serum levels of some tumor markers, mainly the carcinoembryonic antigen (CEA), tissue polypeptide antigen (TPA) and CA 19-9, in predicting tumor reappearance, the real gain in terms of survival remains to be defined. This article reviews the current available data on the clinical role and the usefulness of biochemical monitoring in this tumor type, identifying and discussing the key issues of a rational approach for the use of tumor markers in colorectal cancer patient follow-up programs.

UR - http://www.scopus.com/inward/record.url?scp=0030445631&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030445631&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0030445631

VL - 4

SP - 112

EP - 116

JO - European Journal of Laboratory Medicine

JF - European Journal of Laboratory Medicine

SN - 1122-8652

IS - 2

ER -