Clinical usefulness of cancer Antigen 15-3 in breast cancer patients before and after surgery

Antonella Daniele, Rosa Divella, Paolo Trerotoli, Maria Elena Caringella, Angelo Paradiso, Porzia Casamassima, Ines Abbate, Michele Quaranta, Antonio Mazzocca

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Cancer Antigen 15-3 (CA 15-3) is a tumor-associated antigen used as serum marker for breast cancer surveillance in patients and for monitoring the response to treatment. Aim of this study was to retrospectively evaluate CA 15-3 as a prognostic factor in early detection of breast cancer relapse as well as to analyze the statistical correlation between CA 15-3 levels and clinical-pathological parameters including staging, grading, estrogen and progesterone receptors. Methods: Sera of 726 women with breast carcinoma obtained preoperatively and postoperatively were assayed for CA 15-3 by chemoluminescent immunometric assay. Results: We found that the mean serum CA 15-3 levels in patients before surgery were significantly higher (36.59 U/ml) compared with those of CA 15-3 after surgery (27.11 U/ml). We also found that elevated preoperative serum levels of CA 15-3 were significantly correlated with the presence of metastatic disease. In particular, among 305/700 patients (43,6%) that displayed over cut-off (>40U/ml) preoperative levels of CA 15-3, 94 patients (30,8%) developed advanced disease (metastases to distant sites). By contrast, in a subgroup of 395/700 patients (56.4%) with CA 15.3 serum levels <40U/ml, only 32/305 patients (8%) showed signs of advanced disease during follow-up. Cox regression analysis revealed that only the presence of metastasis and the increased serum levels of CA 15-3 after surgery are significant risk factors for relapse of disease. Conclusion: Elevated preoperative concentrations of CA 15-3 may be a useful predictive factor for cancer progression in postoperative patients.

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalOpen Breast Cancer Journal
Volume5
Issue number1
DOIs
Publication statusPublished - 2013

Keywords

  • Breast cancer
  • CA 15-3
  • Follow-up
  • Metastasis
  • Prognostic marker

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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