Clinical usefulness of laser evoked potentials

M. Valeriani, C. Pazzaglia, G. Cruccu, A. Truini

Research output: Contribution to journalArticlepeer-review


Several papers were published since the first clinical applications of laser evoked potentials (LEPs) in disorders of the nociceptive system. While studies produced until five years ago were mostly addressed at identifying lesions of the nociceptive system, more recent papers used LEPs as an instrumental tool for the diagnosis of neuropathic pain. LEPs have also proved useful in demonstrating the pathophysiological mechanisms underlying different types of neuropathic pain (e.g., paroxystic and ongoing neuropathic pain). This is of utmost importance, as pain treatment should take physiopathological mechanisms, rather than etiology into account. Although there are still some limits for the routine use of LEPs as a diagnostic tool, this review of the literature demonstrates that LEP recording has become mandatory for the functional assessment of patients with hypoalgesia or neuropathic pain.

Original languageEnglish
Pages (from-to)345-353
Number of pages9
JournalNeurophysiologie Clinique / Clinical Neurophysiology
Issue number5
Publication statusPublished - Oct 2012


  • Laser evoked potentials
  • Neuropathic pain
  • Nociception
  • Pain assessment

ASJC Scopus subject areas

  • Clinical Neurology
  • Physiology (medical)
  • Neurology


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