Abstract
The progressively growing knowledge of the pathophysiology of a number of immune-mediated gastrointestinal and liver disorders, including autoimmune atrophic gastritis, coeliac disease, autoimmune enteropathy, inflammatory bowel disease, autoimmune hepatitis, primary sclerosing cholangitis, primary biliary cholangitis and autoimmune pancreatitis, together with the improvement of their detection methods have increased the diagnostic power of serum antibodies. In some cases – coeliac disease and autoimmune atrophic gastritis – they have radically changed gastroenterologists’ diagnostic ability, while in others – autoimmune hepatitis, inflammatory bowel disease and autoimmune pancreatitis – their diagnostic performance is still inadequate. Of note, serum antibody misuse in clinical practice has raised a number of controversies, which may generate confusion in the diagnostic management of the aforementioned disorders. In this review, we critically re-evaluate the usefulness of serum antibodies as biomarkers of immune-mediated gastrointestinal and liver disorders, and discuss their pitfalls and merits.
| Original language | English |
|---|---|
| Pages (from-to) | 947-956 |
| Number of pages | 10 |
| Journal | Digestive and Liver Disease |
| Volume | 49 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - Sep 1 2017 |
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Keywords
- Autoimmune atrophic gastritis
- Autoimmune liver disease
- Autoimmune pancreatitis
- Coeliac disease
- Inflammatory bowel disease
ASJC Scopus subject areas
- Hepatology
- Gastroenterology
Cite this
Clinical usefulness of serum antibodies as biomarkers of gastrointestinal and liver diseases. / Di Sabatino, Antonio; Biagi, Federico; Lenzi, Marco; Frulloni, Luca; Lenti, Marco Vincenzo; Giuffrida, Paolo; Corazza, Gino Roberto.
In: Digestive and Liver Disease, Vol. 49, No. 9, 01.09.2017, p. 947-956.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Clinical usefulness of serum antibodies as biomarkers of gastrointestinal and liver diseases
AU - Di Sabatino, Antonio
AU - Biagi, Federico
AU - Lenzi, Marco
AU - Frulloni, Luca
AU - Lenti, Marco Vincenzo
AU - Giuffrida, Paolo
AU - Corazza, Gino Roberto
PY - 2017/9/1
Y1 - 2017/9/1
N2 - The progressively growing knowledge of the pathophysiology of a number of immune-mediated gastrointestinal and liver disorders, including autoimmune atrophic gastritis, coeliac disease, autoimmune enteropathy, inflammatory bowel disease, autoimmune hepatitis, primary sclerosing cholangitis, primary biliary cholangitis and autoimmune pancreatitis, together with the improvement of their detection methods have increased the diagnostic power of serum antibodies. In some cases – coeliac disease and autoimmune atrophic gastritis – they have radically changed gastroenterologists’ diagnostic ability, while in others – autoimmune hepatitis, inflammatory bowel disease and autoimmune pancreatitis – their diagnostic performance is still inadequate. Of note, serum antibody misuse in clinical practice has raised a number of controversies, which may generate confusion in the diagnostic management of the aforementioned disorders. In this review, we critically re-evaluate the usefulness of serum antibodies as biomarkers of immune-mediated gastrointestinal and liver disorders, and discuss their pitfalls and merits.
AB - The progressively growing knowledge of the pathophysiology of a number of immune-mediated gastrointestinal and liver disorders, including autoimmune atrophic gastritis, coeliac disease, autoimmune enteropathy, inflammatory bowel disease, autoimmune hepatitis, primary sclerosing cholangitis, primary biliary cholangitis and autoimmune pancreatitis, together with the improvement of their detection methods have increased the diagnostic power of serum antibodies. In some cases – coeliac disease and autoimmune atrophic gastritis – they have radically changed gastroenterologists’ diagnostic ability, while in others – autoimmune hepatitis, inflammatory bowel disease and autoimmune pancreatitis – their diagnostic performance is still inadequate. Of note, serum antibody misuse in clinical practice has raised a number of controversies, which may generate confusion in the diagnostic management of the aforementioned disorders. In this review, we critically re-evaluate the usefulness of serum antibodies as biomarkers of immune-mediated gastrointestinal and liver disorders, and discuss their pitfalls and merits.
KW - Autoimmune atrophic gastritis
KW - Autoimmune liver disease
KW - Autoimmune pancreatitis
KW - Coeliac disease
KW - Inflammatory bowel disease
UR - http://www.scopus.com/inward/record.url?scp=85024499871&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85024499871&partnerID=8YFLogxK
U2 - 10.1016/j.dld.2017.06.010
DO - 10.1016/j.dld.2017.06.010
M3 - Review article
AN - SCOPUS:85024499871
VL - 49
SP - 947
EP - 956
JO - Digestive and Liver Disease
JF - Digestive and Liver Disease
SN - 1590-8658
IS - 9
ER -