Clinical usefulness of serum tartrate-resistant acid phosphatase activity determination to evaluate bone turnover

L. Scarnecchia, S. Minisola, M. T. Pacitti, V. Carnevale, E. Romagnoli, R. Rosso, G. F. Mazzuoli

Research output: Contribution to journalArticlepeer-review

Abstract

The study was carried out to evaluate the clinical validity and usefulness of serum tartrate-resistant acid phosphatase (TRAP) activity determined using an improved spectrophotometric assay. Enzyme activity was measured in 84 normal subjects and in 109 patients with common metabolic bone diseases. Mean values of serum TRAP activity in male subjects (n= 19; 10.4 ± 2.15 U1-1) were not significantly different from those found in female subjects (n=65; 10.8 ± 1.8 U 1-1). In the latter group mean values were significantly raised in post-menopausal subjects (10.5 ± 2.0 U l-1; p -1). We found a significant inverse correlation between serum TRAP activity values and bone mineral density (BMD) measured both at an ultradistal radial point (n=33, r = -0.506; p-1, p

Original languageEnglish
Pages (from-to)517-524
Number of pages8
JournalScandinavian Journal of Clinical and Laboratory Investigation
Volume51
Issue number6
DOIs
Publication statusPublished - 1991

Keywords

  • Ageing
  • Alkaline phosphatase
  • Bone mineral density
  • Hydroxyproline
  • Metabolic bone disease
  • Osteocalcin
  • Osteoporosis
  • Primary hyperparathyroidism

ASJC Scopus subject areas

  • Clinical Biochemistry

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