Clinical utility of CA 72-4 serum marker in the staging and immediate post-surgical management of gastric cancer patients

Antonella Spila, Mario Roselli, Maurizio Cosimelli, Patrizia Ferroni, Francesco Cavaliere, Raffaella Arcuri, Manfredo Tedesco, Sandro Carlini, Roberta D'Alessandro, Pasquale Perri, Carlo U. Casciani, John W. Greiner, Jeffrey Schlom, Fiorella Guadagni

Research output: Contribution to journalArticle

Abstract

CA 72-4 is a high molecular weight, pancarcinoma human tumor mucin which may play an important role in the identification (i.e., staging) and clinical management of patients with gastric carcinoma. In the present study of 242 patients with primary or recurrent gastric cancer, a higher percentage of these patients had measurable serum CA 72-4 levels when compared with either CA 19.9 or CEA. Moreover, the presence of positive serum CA 72-4 levels correlated with the presence of lymph node involvement and with the identification of patients with a poor prognosis due to the presence of an advanced stage of gastric cancer. Post-operative monitoring of serum CA 72-4 revealed that the disappearance of CA 72-4 often indicated curative surgery which correlated with a longer disease-free interval. Additional clinical studies are needed to better evaluate the role of CA 72-4 as a serum marker for human gastric carcinoma. Concomitant studies should also focus on what role CA 72-4 may play in the initiation and/or progression of the gastric carcinoma phenotype.

Original languageEnglish
Pages (from-to)2241-2247
Number of pages7
JournalAnticancer Research
Volume16
Issue number4 B
Publication statusPublished - Jul 1996

Keywords

  • CA 19-9
  • CA 72-4
  • CEA
  • Gastric cancer
  • Post-surgical monitoring
  • Serum markers
  • Serum markers' half-life
  • Staging
  • Surgical treatment

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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  • Cite this

    Spila, A., Roselli, M., Cosimelli, M., Ferroni, P., Cavaliere, F., Arcuri, R., Tedesco, M., Carlini, S., D'Alessandro, R., Perri, P., Casciani, C. U., Greiner, J. W., Schlom, J., & Guadagni, F. (1996). Clinical utility of CA 72-4 serum marker in the staging and immediate post-surgical management of gastric cancer patients. Anticancer Research, 16(4 B), 2241-2247.