Clinical utility of estimated glomerular filtration rate in patients undergoing gated SPECT

Michele Coceani, Alessia Gimelli, Clara Carpeggiani, Antonio L'Abbate, Paolo Marzullo

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: Chronic kidney disease is a major risk factor for coronary artery disease (CAD). The aim of the study was to examine the association between estimated glomerular filtration rate (GFR), presence of CAD, and prognosis in patients with reversible perfusion defects at gated single-photon emission computed tomography (g-SPECT). Methods: Six hundred fifty-eight subjects who had undergone stress/rest g-SPECT for evaluation of myocardial ischemia were divided into two groups according to the presence of CAD, defined by a 70% diameter stenosis in at least one major vessel or principal side branch at coronary angiography. Results: GFR was lower in patients with CAD and after adjusting for several clinical characteristics through multivariate logistic regression analysis, reduced (2) GFR remained a significant predictor of CAD (HR 1.80, 95% CI 1.04 to 3.12, P = .036). In addition, reduced GFR was associated with a greater extent of myocardial ischemia, assessed through the summed difference score, as well as with an increase in both total and cardiac mortality. Conclusions: In patients with a positive g-SPECT scan, GFR is an accurate marker of CAD and is directly correlated to the extent of myocardial ischemia. Furthermore, reduced GFR had an adverse impact on survival in this particular population.

Original languageEnglish
Pages (from-to)384-390
Number of pages7
JournalJournal of Nuclear Cardiology
Volume16
Issue number3
DOIs
Publication statusPublished - 2009

Fingerprint

Single-Photon Emission-Computed Tomography
Glomerular Filtration Rate
Coronary Artery Disease
Myocardial Ischemia
Coronary Angiography
Chronic Renal Insufficiency
Pathologic Constriction
Perfusion
Logistic Models
Regression Analysis
Survival
Mortality
Population

Keywords

  • Coronary artery disease
  • Diagnostic and prognostic application
  • Gated SPECT
  • Ischemia
  • Myocardial

ASJC Scopus subject areas

  • Medicine(all)
  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging

Cite this

Clinical utility of estimated glomerular filtration rate in patients undergoing gated SPECT. / Coceani, Michele; Gimelli, Alessia; Carpeggiani, Clara; L'Abbate, Antonio; Marzullo, Paolo.

In: Journal of Nuclear Cardiology, Vol. 16, No. 3, 2009, p. 384-390.

Research output: Contribution to journalArticle

Coceani, Michele ; Gimelli, Alessia ; Carpeggiani, Clara ; L'Abbate, Antonio ; Marzullo, Paolo. / Clinical utility of estimated glomerular filtration rate in patients undergoing gated SPECT. In: Journal of Nuclear Cardiology. 2009 ; Vol. 16, No. 3. pp. 384-390.
@article{e107cf050d8f490aaa5f2134f98864b6,
title = "Clinical utility of estimated glomerular filtration rate in patients undergoing gated SPECT",
abstract = "Background: Chronic kidney disease is a major risk factor for coronary artery disease (CAD). The aim of the study was to examine the association between estimated glomerular filtration rate (GFR), presence of CAD, and prognosis in patients with reversible perfusion defects at gated single-photon emission computed tomography (g-SPECT). Methods: Six hundred fifty-eight subjects who had undergone stress/rest g-SPECT for evaluation of myocardial ischemia were divided into two groups according to the presence of CAD, defined by a 70{\%} diameter stenosis in at least one major vessel or principal side branch at coronary angiography. Results: GFR was lower in patients with CAD and after adjusting for several clinical characteristics through multivariate logistic regression analysis, reduced (2) GFR remained a significant predictor of CAD (HR 1.80, 95{\%} CI 1.04 to 3.12, P = .036). In addition, reduced GFR was associated with a greater extent of myocardial ischemia, assessed through the summed difference score, as well as with an increase in both total and cardiac mortality. Conclusions: In patients with a positive g-SPECT scan, GFR is an accurate marker of CAD and is directly correlated to the extent of myocardial ischemia. Furthermore, reduced GFR had an adverse impact on survival in this particular population.",
keywords = "Coronary artery disease, Diagnostic and prognostic application, Gated SPECT, Ischemia, Myocardial",
author = "Michele Coceani and Alessia Gimelli and Clara Carpeggiani and Antonio L'Abbate and Paolo Marzullo",
year = "2009",
doi = "10.1007/s12350-008-9033-1",
language = "English",
volume = "16",
pages = "384--390",
journal = "Journal of Nuclear Cardiology",
issn = "1071-3581",
publisher = "Springer New York",
number = "3",

}

TY - JOUR

T1 - Clinical utility of estimated glomerular filtration rate in patients undergoing gated SPECT

AU - Coceani, Michele

AU - Gimelli, Alessia

AU - Carpeggiani, Clara

AU - L'Abbate, Antonio

AU - Marzullo, Paolo

PY - 2009

Y1 - 2009

N2 - Background: Chronic kidney disease is a major risk factor for coronary artery disease (CAD). The aim of the study was to examine the association between estimated glomerular filtration rate (GFR), presence of CAD, and prognosis in patients with reversible perfusion defects at gated single-photon emission computed tomography (g-SPECT). Methods: Six hundred fifty-eight subjects who had undergone stress/rest g-SPECT for evaluation of myocardial ischemia were divided into two groups according to the presence of CAD, defined by a 70% diameter stenosis in at least one major vessel or principal side branch at coronary angiography. Results: GFR was lower in patients with CAD and after adjusting for several clinical characteristics through multivariate logistic regression analysis, reduced (2) GFR remained a significant predictor of CAD (HR 1.80, 95% CI 1.04 to 3.12, P = .036). In addition, reduced GFR was associated with a greater extent of myocardial ischemia, assessed through the summed difference score, as well as with an increase in both total and cardiac mortality. Conclusions: In patients with a positive g-SPECT scan, GFR is an accurate marker of CAD and is directly correlated to the extent of myocardial ischemia. Furthermore, reduced GFR had an adverse impact on survival in this particular population.

AB - Background: Chronic kidney disease is a major risk factor for coronary artery disease (CAD). The aim of the study was to examine the association between estimated glomerular filtration rate (GFR), presence of CAD, and prognosis in patients with reversible perfusion defects at gated single-photon emission computed tomography (g-SPECT). Methods: Six hundred fifty-eight subjects who had undergone stress/rest g-SPECT for evaluation of myocardial ischemia were divided into two groups according to the presence of CAD, defined by a 70% diameter stenosis in at least one major vessel or principal side branch at coronary angiography. Results: GFR was lower in patients with CAD and after adjusting for several clinical characteristics through multivariate logistic regression analysis, reduced (2) GFR remained a significant predictor of CAD (HR 1.80, 95% CI 1.04 to 3.12, P = .036). In addition, reduced GFR was associated with a greater extent of myocardial ischemia, assessed through the summed difference score, as well as with an increase in both total and cardiac mortality. Conclusions: In patients with a positive g-SPECT scan, GFR is an accurate marker of CAD and is directly correlated to the extent of myocardial ischemia. Furthermore, reduced GFR had an adverse impact on survival in this particular population.

KW - Coronary artery disease

KW - Diagnostic and prognostic application

KW - Gated SPECT

KW - Ischemia

KW - Myocardial

UR - http://www.scopus.com/inward/record.url?scp=68049142319&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=68049142319&partnerID=8YFLogxK

U2 - 10.1007/s12350-008-9033-1

DO - 10.1007/s12350-008-9033-1

M3 - Article

C2 - 19159995

AN - SCOPUS:68049142319

VL - 16

SP - 384

EP - 390

JO - Journal of Nuclear Cardiology

JF - Journal of Nuclear Cardiology

SN - 1071-3581

IS - 3

ER -