Clinical validation of glucose pump test (GPT) compared with ultrasound dilution technology in arteriovenous graft surveillance

Alberto Magnasco, Giuseppe Bacchini, Antonio Cappello, Vincenzo La Milia, Brigida Brezzi, PierGiorgio G. Messa, Francesco Locatelli

Research output: Contribution to journalArticle

Abstract

Background. Blood flow (Qa) measurements are an important step in the surveillance protocol of haemodialysis vascular access (VA). The glucose pump test (GPT) is a new test for Qa measurement based on the dilution of a constant glucose infusion. The aim of this study is to verify the clinical accuracy of GPT in a graft surveillance protocol with sequential Qa measurements. Methods. In 30 chronic haemodialysis patients with graft, we compared monthly sequential Qa measurements performed with GPT in pre-dialysis and the ultrasound dilution technique (HD01 device Transonic Systems Inc., USA) during dialysis. The colour Doppler ultrasonography study (CDU) was our reference standard for the diagnosis of stenosis. The endpoints were the graft thrombosis or PTA treatment. Results. According to the K/DOQI guidelines we could identify the thrombosis high-risk grafts when Qa was 25% in serial Qa measurements. HD01 yielded 27 of 112 high-risk Qa measurements (21 Qa 25%; mean 43 ± 7%). In 12 of 27 cases the CDU control did not show haemodynamically significant stenoses (false positive); 15 of 27 cases were confirmed high-risk accesses by CDU and did PTAs (HD01 specificity 86%). GPT yielded 14 of 112 high-risk Qa measurements (8 Qa 25%; mean 38 ± 8%) and all had severe stenoses and underwent PTA treatments showing a GPT specificity of 100%. The CDU study allowed us to correctly assess the Qa negative cases. HD01 method had 10 false negative cases (treated or clotted grafts with a Qa >600ml/min and Δ Qa

Original languageEnglish
Pages (from-to)1835-1841
Number of pages7
JournalNephrology Dialysis Transplantation
Volume19
Issue number7
DOIs
Publication statusPublished - Jun 2004

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Keywords

  • Colour Doppler ultrasound
  • Haemodialysis
  • Ultrasound dilution technology
  • Vascular access

ASJC Scopus subject areas

  • Nephrology
  • Transplantation

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