Clinical value of botulinum toxin in neurological indications

A. B. Ward, G. Molenaers, C. Colosimo, A. Berardelli

Research output: Contribution to journalArticlepeer-review


Botulinum toxin type-A (BoNT-A) prevents the release of acetylcholine at cholinergic junctions, thereby causing temporary muscle weakness lasting 3-4 months. It is now widely used to treat a broad range of clinical disorders characterized by muscle hyperactivity. BoNT-A has proved effective in the management of several neurological conditions and, in particular, in the management of movement disorders (e.g. blepharospasm, cervical dystonia, laryngeal dystonia, limb dystonia, hemifacial spasm, focal tics, tremor and other hyperkinetic disorders). As a treatment of spasticity, BoNT-A can improve mobility and dexterity as well as preventing the development of distressing and costly secondary complications. In cerebral palsy, BoNT-A is of value, being able to delay or even avoid surgery until motion patterns have become established.

Original languageEnglish
Pages (from-to)20-26
Number of pages7
JournalEuropean Journal of Neurology
Issue numberSUPPL. 4
Publication statusPublished - Dec 2006


  • BOTOX®
  • Botulinum toxin type-A
  • Cerebral palsy
  • Movement disorders
  • Spasticity
  • Urology

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)


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