Clinical value of the measurement of bone remodelling markers in primary hyperparathyroidism

S. Minisola, L. Scarnecchia, V. Carnevale, F. Bigi, E. Romagnoli, M. T. Pacitti, R. Rosso, G. F. Mazzuoli

Research output: Contribution to journalArticlepeer-review

Abstract

This study was performed in order to evaluate the clinical usefulness of the measurement of total serum alkaline phosphatase activity (AP), serum osteocalcin (BGP) and urinary hydroxyproline (OHPr) in assessing bone remodelling in primary hyperparathyroidism. Thirty-two patients with primary hyperparathyroidism were included in the study. No statistically significant differences were observed between the mean values of Z-scores obtained for each marker. Furthermore, an inverse correlation was found between percentage of bone mineral content at the distal radius and both BGP (r = −0.57; p <0.05) and AP (r = −0.49; p <0.05). The results obtained demonstrate that, contrary to other metabolic bone diseases (e.g. Paget’s disease of bone), all three markers examined may be used in clinical practice to evaluate the entity of skeletal turnover in primary hyperparathyroidism.

Original languageEnglish
Pages (from-to)537-542
Number of pages6
JournalJournal of Endocrinological Investigation
Volume12
Issue number8
DOIs
Publication statusPublished - 1989

Keywords

  • bone mineral content
  • bone turnover
  • Hyperparathyroidism
  • serum alkaline phosphatase activity
  • serum osteocalcin
  • urinary hydroxyproline

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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