Clinical variability in children with dolichoarteriopathies of the internal carotid artery: Child's Nervous System

T. Foiadelli, R. Ippolito, R. Corbetta, A.M. Simoncelli, R. Amariti, A. Licari, G. Marseglia, S. Savasta

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: Dolichoarteriopathies of the internal carotid artery (DICA) are frequent non-atheromatous anatomical changes in the general population. The etiology of DICA is still controversial: several hypotheses have been suggested, including an anomaly of embryological development, or a degenerative loss of elasticity of the vessel wall. DICA have been related to a wide spectrum of clinical presentations in adults, varying from asymptomatic forms to acute cerebrovascular events. However, to date, only a few pediatric cases have been reported. Methods and results: We report seven patients with DICA, 6 males and 1 female, aged 3 to 13 years, presenting with variable clinical symptoms. Different imaging techniques, including color Doppler ultrasound and magnetic resonance angiography, were used to show loops and/or kinking of the ICA. Three of these patients received a diagnosis of Ehlers-Danlos syndrome (EDS). Discussion: This study highlights the clinical variability in pediatric patients with DICA. We emphasize the need for close clinical management of pediatric DICA. Finally, considering the long-term prognostic implications of EDS, we recommend specific testing in children with DICA and suspicious clinical signs of this pathology.

Original languageEnglish
Pages (from-to)621-628
Number of pages8
JournalChild's Nerv. Syst.
Volume36
Issue number3
DOIs
Publication statusPublished - 2020

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