Clinically isolated syndrome suggestive of multiple sclerosis: Dynamic patterns of gray and white matter changes - A 2-year MR imaging study

Maria A. Rocca, Paolo Preziosa, Sarlota Mesaros, Elisabetta Pagani, Jelena Dackovic, Tatjana Stosic-Opincal, Jelena Drulovic, Massimo Filippi

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: To investigate the patterns of regional gray matter (GM) and white matter (WM) atrophy, WM microstructural tissue damage, and changes in patients with a clinically isolated syndrome (CIS) suggestive of multiple sclerosis at 2 years from clinical onset. Materials and Methods: Institutional review board approval and written informed consent from all patients were obtained. Neurologic assessment and conventional, diffusion-tensor, and volumetric brain MR imaging sequences were performed in 37 patients with CIS within 2 months of clinical onset, and after 3, 12, and 24 months. Fourteen healthy control subjects also were studied. Longitudinal GM and WM volume changes and WM microstructural abnormalities were assessed by using voxel-based morphometry (P

Original languageEnglish
Pages (from-to)841-853
Number of pages13
JournalRadiology
Volume278
Issue number3
DOIs
Publication statusPublished - Mar 1 2016

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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