Clinically isolated syndromes suggestive of multiple sclerosis, part I: Natural history, pathogenesis, diagnosis, and prognosis

David Miller, Frederik Barkhof, Xavier Montalban, Alan Thompson, Massimo Filippi

Research output: Contribution to journalArticle

371 Citations (Scopus)

Abstract

In 85% of young adults with multiple sclerosis (MS), onset is a subacute clinically isolated syndrome (CIS) of the optic nerves, brainstem, or spinal cord. Methods of assessing the prognosis for patients who present with a CIS have been sought, because only 30-70% of patients with a CIS develop MS. When clinically silent brain lesions are seen on MRI, the likelihood of developing MS is high. MS can be diagnosed within 3 months of CIS presentation with certain MRI and CSF criteria. Disability from MS is less likely in patients with a CIS of optic neuritis or sensory symptoms only, few or no MRI lesions, a long period to the first relapse, and no disability after the first 5 years. Development of more reliable prognostic markers will enable new treatments to be targeted for those who are most likely to benefit. We encourage continued clinical and laboratory assessment of patients with a CIS.

Original languageEnglish
Pages (from-to)281-288
Number of pages8
JournalThe Lancet Neurology
Volume4
Issue number5
DOIs
Publication statusPublished - May 1 2005

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Natural History
Multiple Sclerosis
Optic Neuritis
Optic Nerve
Brain Stem
Young Adult
Spinal Cord
Recurrence
Brain

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Clinically isolated syndromes suggestive of multiple sclerosis, part I : Natural history, pathogenesis, diagnosis, and prognosis. / Miller, David; Barkhof, Frederik; Montalban, Xavier; Thompson, Alan; Filippi, Massimo.

In: The Lancet Neurology, Vol. 4, No. 5, 01.05.2005, p. 281-288.

Research output: Contribution to journalArticle

Miller, David ; Barkhof, Frederik ; Montalban, Xavier ; Thompson, Alan ; Filippi, Massimo. / Clinically isolated syndromes suggestive of multiple sclerosis, part I : Natural history, pathogenesis, diagnosis, and prognosis. In: The Lancet Neurology. 2005 ; Vol. 4, No. 5. pp. 281-288.
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