This review article is focused on some qualifying pharmacotherapeutic aspects of the management of schizophrenia such as the relevance of early therapeutic intervention, the role of relapse for cronicity, partial or poor response and suicidality with particular reference to the use of novel compounds. Duration of Untreated Psychosis (DUP) is considered as a potential predictor of the outcome in schizophrenia: there is the hypothesis that a longer DUP may play a role on the potential neurotoxicity, cognitive deterioration and poor response to neuroleptics. Particular interest is arising on the ability of new compounds for a better prevention of relapses and ameliorating drug compliance (compared to neuroleptics): in fact, the prophylactic activity of conventional antipsychotics is far from being satisfactory considering the high percentage of patients who relapse despite continuous treatment. Moreover, the use of new compounds has influenced basic neurochemical hypothesis on the biopathogenesis of schizophrenia: in this light drug resistance has been studied with particular respect to factors influencing treatment-response such as pharmacodynamic and pharmacokinetic variables, and some neuro-immune-endocrine correlates that can be responsible for differences in response between old and new antipsychotics. Finally, some comments about mortality in schizophrenia. People with a diagnosis of schizophrenia can expect to live 9-12 years shorter, on average, than the general population. The reasons for this mortality excess in schizophrenic patients is analysed. The use of new compounds has contributed to new conceptualizations about the bio-pathogenic model for schizophrenia and has also encouraged research into the above mentioned directions.
|Translated title of the contribution||Clinical/therapeutic patterns in Schizophrenia: The impact of the novel antipsychotics|
|Number of pages||16|
|Journal||Rivista di Psichiatria|
|Publication status||Published - Mar 2006|
ASJC Scopus subject areas
- Psychiatry and Mental health