Clinico-prognostic implications of increased levels of soluble CD54 in the serum of B-cell chronic lymphocytic leukemia patients. Results of a multivariate survival analysis

Stefano Molica, Domenico Levato, Matteo Dell'Olio, Nicola Cascavilla, Rossella Matera, Marta Minervini, Angela Dattilo, Mario Carotenuto, Pellegrino Musto

Research output: Contribution to journalArticle

Abstract

Background and Objective. Although less specific than sCD23, sCD54 levels have clinico-prognostic relevance in B-cell chronic lymphocytic leukemia (CLL). Since serological markers are now emerging as potentially important in CLL, we tried to verify whether sCD54 might complement clinical stages. Methods. Serum levels of sCD54 were determined at the time of diagnosis in 115 previously untreated CLL patients. Results were correlated with clinicobiological parameters as well as with survival. Results. Life- expectancy was significantly shorter in patients with higher serum levels of sCD54 (p <0.001); however, in a Cox's multivariate survival analysis, the only variables which entered the regression model at a significant level were bone marrow (BFA) histology (p = 0.03) and lymphocyte doubling time (LDT) (p = 0.04). Interestingly, when LDT was excluded from analysis the only significant variables were clinical stages (p <0.05) and sCD54 (p <0.05). These results suggest that sCD54 and LDT give similar prognostic information. Interpretation and Conclusions. In CLL, sCD54 is a reliable prognostic parameter whose value is independent of clinical stages. When investigated in relation to clinical outcome, serum levels of sCD54 were able to predict progression to a more advanced clinical stage. On the basis of these data, an integrated clinico-biological classification which separates intermediate risk into two prognostic subgroups is proposed.

Original languageEnglish
Pages (from-to)148-151
Number of pages4
JournalHaematologica
Volume82
Issue number2
Publication statusPublished - Mar 1997

Keywords

  • Chronic lymphocytic leukemia
  • sCD54
  • Staging prognosis

ASJC Scopus subject areas

  • Hematology

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    Molica, S., Levato, D., Dell'Olio, M., Cascavilla, N., Matera, R., Minervini, M., Dattilo, A., Carotenuto, M., & Musto, P. (1997). Clinico-prognostic implications of increased levels of soluble CD54 in the serum of B-cell chronic lymphocytic leukemia patients. Results of a multivariate survival analysis. Haematologica, 82(2), 148-151.