Clinico-radiological monitoring strategies in patients with metastatic breast cancer: A real-world study

Marta Bonotto, Debora Basile, Lorenzo Gerratana, Michele Bartoletti, Camilla Lisanti, Giacomo Pelizzari, Maria Grazia Vitale, Valentina Fanotto, Elena Poletto, Alessandro Marco Minisini, Stefania Russo, Claudia Andreetta, Mauro Mansutti, Gianpiero Fasola, Fabio Puglisi

Research output: Contribution to journalArticlepeer-review


Aim: A monitoring strategy for metastatic breast cancer patients (M-MBC) has been little studied. Materials & methods: This retrospective study analyzed a consecutive cohort of 382 MBC patients to analyze different M-MBC strategies to identify factors influencing intensive M-MBC. Results: Elevated baseline serum tumor markers (STM) was the strongest factor associated with increased use of STM tests. Having more frequent oncology office visits was associated with more intensive chemotherapy/magnetic resonance imaging (MRI) using. Increased use of imaging tests was associated with participation to clinical trial. Single and elderly patients were less likely to have frequent testing. Having clinically measurable disease was less likely to have more intensive M-MBC. Conclusion: STM testing and scans were frequently ordered in M-MBC. In the present study, strategies are little influenced by clinico-pathological characteristics.

Original languageEnglish
Pages (from-to)2059-2073
Number of pages15
JournalFuture Oncology
Issue number27
Publication statusPublished - Sep 2020


  • Breast cancer
  • determinants of monitoring
  • metastatic breast cancer
  • monitoring breast cancer
  • monitoring strategies

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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