STUDIO CLINICO-IMMUNOLOGICO DI SEI CASI DI MORBO DI BEHCET

Translated title of the contribution: Clinicoimmunological study of six cases of Behcet's disease

V. Silingardi, C. Montemurno, L. Venezia, C. Franceschi, P. C. Riva, G. Emilia, M. Masi, E. Merelli, G. Torelli, F. Licastro, M. P. Fantini, M. Federico

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

6 cases of Behcet's disease are reported. Diagnosis was particularly arduous because the typical triad of symptoms (oral aphthae, genital ulcers, uveitis) was masked by secondary disturbances in other organs and systems. Immunology confirmed the presence in these patients of changes in various in vivo and in vitro tests and particularly interesting was the aspecific cutaneous hypersensitivity seen in 5 cases and enhanced lymphocyte blastic transformation. This was seen spontaneously and following PHA. On the basis of the outcome of the studies carried out and the literature data, the possibility that Behcet's disease may contain immunological changes and changes in the mechanisms that regulate quinine, complement and clotting activation is suggested. Therapeutically, confirmation was obtained of effectiveness, at least temporarily, of corticosteroid treatment and antilymphocyte globulin was experimented for the first time in these patients. This might be used to replace the immune depressant antiblastic substances already successfully employed in patients with Behcet's disease.

Original languageItalian
Pages (from-to)3269-3284
Number of pages16
JournalMinerva Medica
Volume70
Issue number48
Publication statusPublished - 1979

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Behcet Syndrome
Aphthous Stomatitis
Antilymphocyte Serum
Quinine
Complement Activation
Uveitis
Lymphocyte Activation
Allergy and Immunology
Ulcer
Adrenal Cortex Hormones
Hypersensitivity
Outcome Assessment (Health Care)
Skin
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Silingardi, V., Montemurno, C., Venezia, L., Franceschi, C., Riva, P. C., Emilia, G., ... Federico, M. (1979). STUDIO CLINICO-IMMUNOLOGICO DI SEI CASI DI MORBO DI BEHCET. Minerva Medica, 70(48), 3269-3284.

STUDIO CLINICO-IMMUNOLOGICO DI SEI CASI DI MORBO DI BEHCET. / Silingardi, V.; Montemurno, C.; Venezia, L.; Franceschi, C.; Riva, P. C.; Emilia, G.; Masi, M.; Merelli, E.; Torelli, G.; Licastro, F.; Fantini, M. P.; Federico, M.

In: Minerva Medica, Vol. 70, No. 48, 1979, p. 3269-3284.

Research output: Contribution to journalArticle

Silingardi, V, Montemurno, C, Venezia, L, Franceschi, C, Riva, PC, Emilia, G, Masi, M, Merelli, E, Torelli, G, Licastro, F, Fantini, MP & Federico, M 1979, 'STUDIO CLINICO-IMMUNOLOGICO DI SEI CASI DI MORBO DI BEHCET', Minerva Medica, vol. 70, no. 48, pp. 3269-3284.
Silingardi V, Montemurno C, Venezia L, Franceschi C, Riva PC, Emilia G et al. STUDIO CLINICO-IMMUNOLOGICO DI SEI CASI DI MORBO DI BEHCET. Minerva Medica. 1979;70(48):3269-3284.
Silingardi, V. ; Montemurno, C. ; Venezia, L. ; Franceschi, C. ; Riva, P. C. ; Emilia, G. ; Masi, M. ; Merelli, E. ; Torelli, G. ; Licastro, F. ; Fantini, M. P. ; Federico, M. / STUDIO CLINICO-IMMUNOLOGICO DI SEI CASI DI MORBO DI BEHCET. In: Minerva Medica. 1979 ; Vol. 70, No. 48. pp. 3269-3284.
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AU - Riva, P. C.

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AU - Masi, M.

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AB - 6 cases of Behcet's disease are reported. Diagnosis was particularly arduous because the typical triad of symptoms (oral aphthae, genital ulcers, uveitis) was masked by secondary disturbances in other organs and systems. Immunology confirmed the presence in these patients of changes in various in vivo and in vitro tests and particularly interesting was the aspecific cutaneous hypersensitivity seen in 5 cases and enhanced lymphocyte blastic transformation. This was seen spontaneously and following PHA. On the basis of the outcome of the studies carried out and the literature data, the possibility that Behcet's disease may contain immunological changes and changes in the mechanisms that regulate quinine, complement and clotting activation is suggested. Therapeutically, confirmation was obtained of effectiveness, at least temporarily, of corticosteroid treatment and antilymphocyte globulin was experimented for the first time in these patients. This might be used to replace the immune depressant antiblastic substances already successfully employed in patients with Behcet's disease.

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