Clinicopathologic analysis of 370 cases of vulvar intraepithelial neoplasia

Alberto Agarossi, Giuseppe Atlante, Lucia Baldi, Maggiorino Barbero, Salvatore Bennici, Albino Bianchi, Giovanni Borgno, Gian Luca Bracco, Maria Teresa Bruno, Alfonsina Buscemi, Marco Canni, Silvestro Carinelli, Paolo Carli, Antonio Cattaneo, Angelo Cavagnini, Mario Conti, Silvano Costa, Luigi De Cecco, Antonio De Marco, Roberta De SanctisLuisa Dragoni, Marcella Falchetti, Augusto Ferrari, Daniela Gerbaldo, Bruno Ghiringhello, Gerardo Guida, Maurizio Leone, Maria Pia Maresi, Luciano Mariani, Giuseppe Martinelli, Concettina Matarazzo, Leonardo Micheletti, Luciano Minissale, Maria Luisa Muggiasca, Patrizia Nicolaci, Giuseppe Nuciforo, Massimo Origoni, Giuseppe Palumbo, Emanuela Prati, Mario Preti, Giuseppe Pulvirenti, Fabio Rampinelli, Francesco Sciarretta, Mario Sideri, Lorella Sonni, Gian Luigi Taddei, Calogero Vendra, Annarosa Virgili, Riccardo Vigano, Maria Clara Zanotto Valentino

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: To investigate epidemiologic, clinical and pathologic aspects of various grades of vulvar intraepithelial neoplasia (VIN). STUDY DESIGN: A retrospective, multicenter study of 370 cases of vulvar intraepithelial neoplasia (VIN) was performed by the Italian Study Group on Vulvar Disease. RESULTS: Of the 370 cases, 148 were VIN 1 (40.0%), 53 were VIN 2 (14.3%), and 169 were VIN 3 (45.7%). The mean age of the patients was 52.6 years. During the study period an increase in the rate of human papillomavirus-associated VIN was observed. In addition, while VIN 1 and 2 were associated mostly with squamous cell hyperplasia, VIN 3 was almost equally associated with lichen sclerosus and squamous cell hyperplasia; the difference was statistically significant. Intraepithelial or invasive squamous neoplasia of the lower genital tract was associated in 22% of the cases (82/370). CONCLUSION: The results of the investigation, although not allowing firm conclusions due to the retrospective and multicentered nature of the study, demonstrate the extreme heterogeneity of VIN lesions.

Original languageEnglish
Pages (from-to)665-670
Number of pages6
JournalJournal of Reproductive Medicine for the Obstetrician and Gynecologist
Volume41
Issue number9
Publication statusPublished - Sep 1996

Keywords

  • vulvar neoplasms

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine

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