Clinicopathologic analysis of 370 cases of vulvar intraepithelial neoplasia

Alberto Agarossi, Giuseppe Atlante, Lucia Baldi, Maggiorino Barbero, Salvatore Bennici, Albino Bianchi, Giovanni Borgno, Gian Luca Bracco, Maria Teresa Bruno, Alfonsina Buscemi, Marco Canni, Silvestro Carinelli, Paolo Carli, Antonio Cattaneo, Angelo Cavagnini, Mario Conti, Silvano Costa, Luigi De Cecco, Antonio De Marco, Roberta De Sanctis & 30 others Luisa Dragoni, Marcella Falchetti, Augusto Ferrari, Daniela Gerbaldo, Bruno Ghiringhello, Gerardo Guida, Maurizio Leone, Maria Pia Maresi, Luciano Mariani, Giuseppe Martinelli, Concettina Matarazzo, Leonardo Micheletti, Luciano Minissale, Maria Luisa Muggiasca, Patrizia Nicolaci, Giuseppe Nuciforo, Massimo Origoni, Giuseppe Palumbo, Emanuela Prati, Mario Preti, Giuseppe Pulvirenti, Fabio Rampinelli, Francesco Sciarretta, Mario Sideri, Lorella Sonni, Gian Luigi Taddei, Calogero Vendra, Annarosa Virgili, Riccardo Vigano, Maria Clara Zanotto Valentino

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

OBJECTIVE: To investigate epidemiologic, clinical and pathologic aspects of various grades of vulvar intraepithelial neoplasia (VIN). STUDY DESIGN: A retrospective, multicenter study of 370 cases of vulvar intraepithelial neoplasia (VIN) was performed by the Italian Study Group on Vulvar Disease. RESULTS: Of the 370 cases, 148 were VIN 1 (40.0%), 53 were VIN 2 (14.3%), and 169 were VIN 3 (45.7%). The mean age of the patients was 52.6 years. During the study period an increase in the rate of human papillomavirus-associated VIN was observed. In addition, while VIN 1 and 2 were associated mostly with squamous cell hyperplasia, VIN 3 was almost equally associated with lichen sclerosus and squamous cell hyperplasia; the difference was statistically significant. Intraepithelial or invasive squamous neoplasia of the lower genital tract was associated in 22% of the cases (82/370). CONCLUSION: The results of the investigation, although not allowing firm conclusions due to the retrospective and multicentered nature of the study, demonstrate the extreme heterogeneity of VIN lesions.

Original languageEnglish
Pages (from-to)665-670
Number of pages6
JournalJournal of Reproductive Medicine for the Obstetrician and Gynecologist
Volume41
Issue number9
Publication statusPublished - Sep 1996

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Neoplasms
Hyperplasia
Vulvar Diseases
Epithelial Cells
Lichen Sclerosus et Atrophicus
Multicenter Studies
Retrospective Studies

Keywords

  • vulvar neoplasms

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine

Cite this

Agarossi, A., Atlante, G., Baldi, L., Barbero, M., Bennici, S., Bianchi, A., ... Zanotto Valentino, M. C. (1996). Clinicopathologic analysis of 370 cases of vulvar intraepithelial neoplasia. Journal of Reproductive Medicine for the Obstetrician and Gynecologist, 41(9), 665-670.

Clinicopathologic analysis of 370 cases of vulvar intraepithelial neoplasia. / Agarossi, Alberto; Atlante, Giuseppe; Baldi, Lucia; Barbero, Maggiorino; Bennici, Salvatore; Bianchi, Albino; Borgno, Giovanni; Luca Bracco, Gian; Teresa Bruno, Maria; Buscemi, Alfonsina; Canni, Marco; Carinelli, Silvestro; Carli, Paolo; Cattaneo, Antonio; Cavagnini, Angelo; Conti, Mario; Costa, Silvano; De Cecco, Luigi; De Marco, Antonio; De Sanctis, Roberta; Dragoni, Luisa; Falchetti, Marcella; Ferrari, Augusto; Gerbaldo, Daniela; Ghiringhello, Bruno; Guida, Gerardo; Leone, Maurizio; Pia Maresi, Maria; Mariani, Luciano; Martinelli, Giuseppe; Matarazzo, Concettina; Micheletti, Leonardo; Minissale, Luciano; Luisa Muggiasca, Maria; Nicolaci, Patrizia; Nuciforo, Giuseppe; Origoni, Massimo; Palumbo, Giuseppe; Prati, Emanuela; Preti, Mario; Pulvirenti, Giuseppe; Rampinelli, Fabio; Sciarretta, Francesco; Sideri, Mario; Sonni, Lorella; Luigi Taddei, Gian; Vendra, Calogero; Virgili, Annarosa; Vigano, Riccardo; Zanotto Valentino, Maria Clara.

In: Journal of Reproductive Medicine for the Obstetrician and Gynecologist, Vol. 41, No. 9, 09.1996, p. 665-670.

Research output: Contribution to journalArticle

Agarossi, A, Atlante, G, Baldi, L, Barbero, M, Bennici, S, Bianchi, A, Borgno, G, Luca Bracco, G, Teresa Bruno, M, Buscemi, A, Canni, M, Carinelli, S, Carli, P, Cattaneo, A, Cavagnini, A, Conti, M, Costa, S, De Cecco, L, De Marco, A, De Sanctis, R, Dragoni, L, Falchetti, M, Ferrari, A, Gerbaldo, D, Ghiringhello, B, Guida, G, Leone, M, Pia Maresi, M, Mariani, L, Martinelli, G, Matarazzo, C, Micheletti, L, Minissale, L, Luisa Muggiasca, M, Nicolaci, P, Nuciforo, G, Origoni, M, Palumbo, G, Prati, E, Preti, M, Pulvirenti, G, Rampinelli, F, Sciarretta, F, Sideri, M, Sonni, L, Luigi Taddei, G, Vendra, C, Virgili, A, Vigano, R & Zanotto Valentino, MC 1996, 'Clinicopathologic analysis of 370 cases of vulvar intraepithelial neoplasia', Journal of Reproductive Medicine for the Obstetrician and Gynecologist, vol. 41, no. 9, pp. 665-670.
Agarossi A, Atlante G, Baldi L, Barbero M, Bennici S, Bianchi A et al. Clinicopathologic analysis of 370 cases of vulvar intraepithelial neoplasia. Journal of Reproductive Medicine for the Obstetrician and Gynecologist. 1996 Sep;41(9):665-670.
Agarossi, Alberto ; Atlante, Giuseppe ; Baldi, Lucia ; Barbero, Maggiorino ; Bennici, Salvatore ; Bianchi, Albino ; Borgno, Giovanni ; Luca Bracco, Gian ; Teresa Bruno, Maria ; Buscemi, Alfonsina ; Canni, Marco ; Carinelli, Silvestro ; Carli, Paolo ; Cattaneo, Antonio ; Cavagnini, Angelo ; Conti, Mario ; Costa, Silvano ; De Cecco, Luigi ; De Marco, Antonio ; De Sanctis, Roberta ; Dragoni, Luisa ; Falchetti, Marcella ; Ferrari, Augusto ; Gerbaldo, Daniela ; Ghiringhello, Bruno ; Guida, Gerardo ; Leone, Maurizio ; Pia Maresi, Maria ; Mariani, Luciano ; Martinelli, Giuseppe ; Matarazzo, Concettina ; Micheletti, Leonardo ; Minissale, Luciano ; Luisa Muggiasca, Maria ; Nicolaci, Patrizia ; Nuciforo, Giuseppe ; Origoni, Massimo ; Palumbo, Giuseppe ; Prati, Emanuela ; Preti, Mario ; Pulvirenti, Giuseppe ; Rampinelli, Fabio ; Sciarretta, Francesco ; Sideri, Mario ; Sonni, Lorella ; Luigi Taddei, Gian ; Vendra, Calogero ; Virgili, Annarosa ; Vigano, Riccardo ; Zanotto Valentino, Maria Clara. / Clinicopathologic analysis of 370 cases of vulvar intraepithelial neoplasia. In: Journal of Reproductive Medicine for the Obstetrician and Gynecologist. 1996 ; Vol. 41, No. 9. pp. 665-670.
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abstract = "OBJECTIVE: To investigate epidemiologic, clinical and pathologic aspects of various grades of vulvar intraepithelial neoplasia (VIN). STUDY DESIGN: A retrospective, multicenter study of 370 cases of vulvar intraepithelial neoplasia (VIN) was performed by the Italian Study Group on Vulvar Disease. RESULTS: Of the 370 cases, 148 were VIN 1 (40.0{\%}), 53 were VIN 2 (14.3{\%}), and 169 were VIN 3 (45.7{\%}). The mean age of the patients was 52.6 years. During the study period an increase in the rate of human papillomavirus-associated VIN was observed. In addition, while VIN 1 and 2 were associated mostly with squamous cell hyperplasia, VIN 3 was almost equally associated with lichen sclerosus and squamous cell hyperplasia; the difference was statistically significant. Intraepithelial or invasive squamous neoplasia of the lower genital tract was associated in 22{\%} of the cases (82/370). CONCLUSION: The results of the investigation, although not allowing firm conclusions due to the retrospective and multicentered nature of the study, demonstrate the extreme heterogeneity of VIN lesions.",
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AU - Atlante, Giuseppe

AU - Baldi, Lucia

AU - Barbero, Maggiorino

AU - Bennici, Salvatore

AU - Bianchi, Albino

AU - Borgno, Giovanni

AU - Luca Bracco, Gian

AU - Teresa Bruno, Maria

AU - Buscemi, Alfonsina

AU - Canni, Marco

AU - Carinelli, Silvestro

AU - Carli, Paolo

AU - Cattaneo, Antonio

AU - Cavagnini, Angelo

AU - Conti, Mario

AU - Costa, Silvano

AU - De Cecco, Luigi

AU - De Marco, Antonio

AU - De Sanctis, Roberta

AU - Dragoni, Luisa

AU - Falchetti, Marcella

AU - Ferrari, Augusto

AU - Gerbaldo, Daniela

AU - Ghiringhello, Bruno

AU - Guida, Gerardo

AU - Leone, Maurizio

AU - Pia Maresi, Maria

AU - Mariani, Luciano

AU - Martinelli, Giuseppe

AU - Matarazzo, Concettina

AU - Micheletti, Leonardo

AU - Minissale, Luciano

AU - Luisa Muggiasca, Maria

AU - Nicolaci, Patrizia

AU - Nuciforo, Giuseppe

AU - Origoni, Massimo

AU - Palumbo, Giuseppe

AU - Prati, Emanuela

AU - Preti, Mario

AU - Pulvirenti, Giuseppe

AU - Rampinelli, Fabio

AU - Sciarretta, Francesco

AU - Sideri, Mario

AU - Sonni, Lorella

AU - Luigi Taddei, Gian

AU - Vendra, Calogero

AU - Virgili, Annarosa

AU - Vigano, Riccardo

AU - Zanotto Valentino, Maria Clara

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N2 - OBJECTIVE: To investigate epidemiologic, clinical and pathologic aspects of various grades of vulvar intraepithelial neoplasia (VIN). STUDY DESIGN: A retrospective, multicenter study of 370 cases of vulvar intraepithelial neoplasia (VIN) was performed by the Italian Study Group on Vulvar Disease. RESULTS: Of the 370 cases, 148 were VIN 1 (40.0%), 53 were VIN 2 (14.3%), and 169 were VIN 3 (45.7%). The mean age of the patients was 52.6 years. During the study period an increase in the rate of human papillomavirus-associated VIN was observed. In addition, while VIN 1 and 2 were associated mostly with squamous cell hyperplasia, VIN 3 was almost equally associated with lichen sclerosus and squamous cell hyperplasia; the difference was statistically significant. Intraepithelial or invasive squamous neoplasia of the lower genital tract was associated in 22% of the cases (82/370). CONCLUSION: The results of the investigation, although not allowing firm conclusions due to the retrospective and multicentered nature of the study, demonstrate the extreme heterogeneity of VIN lesions.

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