Clinicopathologic and immunologic characteristics of non-hodgkins's lymphomas presenting in the orbit. A report of eight cases

M. Lazzarino, E. Morra, R. Rosso, E. Brusamolino, G. Pagnucco, A. Castello, A. Ghisolfi, A. Tafi, G. Zennaro, C. Bernasconi

Research output: Contribution to journalArticlepeer-review

Abstract

Of 325 consecutive cases of non-Hodgkin's malignant lymphomas, 8 patients (2.4%) showed orbital presentation. The clinicopathologic and immunologic analysis of the eight patients revealed characteristic biologic features. Despite the apparently isolated orbital presentation, all cases had subclinical systemic disease. Seven of the eight cases exhibited lymphoplasmacytic/cytoid features, with concurrent type II cryoblobulinemia in five of them. In addition, during their clinical coure, five patients showed single or multiple subcutaneous nodules with the same histologic and immunologic pattern as the orbital tumor. This study demonstrates that most orbital lymphomas share particular clinicopathologic and immunologic features, suggesting an origin from a B-cell subset with preferential homing to orbital tissues and subcutis.

Original languageEnglish
Pages (from-to)1907-1912
Number of pages6
JournalCancer
Volume55
Issue number9
DOIs
Publication statusPublished - 1985

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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