Clinicopathologic characteristics and treatment of marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma)

Markus Raderer, Barbara Kiesewetter, Andrés J M Ferreri

Research output: Contribution to journalArticlepeer-review


Answer questions and earn CME/CNE Extranodal marginal zone lymphoma of the mucosa-associated lymphoid tissue (MALT lymphoma) accounts for 7% to 8% of newly diagnosed lymphomas. Because of its association with infectious causes, such as Helicobacter pylori (HP) or Chlamydophila psittaci (CP), and autoimmune diseases, it has become the paradigm of an antigen-driven malignancy. MALT lymphoma usually displays an indolent course, and watch-and-wait strategies are justified initially in a certain percentage of patients. In patients with gastric MALT lymphoma or ocular adnexal MALT lymphoma, antibiotic therapy against HP or CP, respectively, is the first-line management of choice, resulting in lymphoma response rates from 75% to 80% after HP eradication and from 33% to 65% after antibiotic therapy for CP. In patients who have localized disease that is refractory to antibiotics, radiation is widely applied in various centers with excellent local control, whereas systemic therapies are increasingly being applied, at least in Europe, because of the potentially systemic nature of the disease. Therefore, the objective of this review is to briefly summarize the clinicopathologic characteristics of this distinct type of lymphoma along with current data on management strategies.

Original languageEnglish
Pages (from-to)152-171
Number of pages20
JournalCa-A Cancer Journal for Clinicians
Issue number2
Publication statusPublished - Mar 1 2016


  • antigen-driven malignancy
  • Chlamydophila psittaci
  • extranodal
  • Helicobacter pylori
  • non-Hodgkin lymphoma

ASJC Scopus subject areas

  • Oncology
  • Hematology


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