TY - JOUR
T1 - Clinicopathologic characteristics of invasive lobular carcinoma of the breast
T2 - Results of an analysis of 530 cases from a single institution
AU - Orvieto, Enrico
AU - Maiorano, Eugenio
AU - Bottiglieri, Luca
AU - Maisonneuve, Patrick
AU - Rotmensz, Nicole
AU - Galimberti, Viviana
AU - Luini, Alberto
AU - Brenelli, Fabricio
AU - Gatti, Giovanna
AU - Viale, Giuseppe
PY - 2008/10/1
Y1 - 2008/10/1
N2 - BACKGROUND. Although invasive lobular carcinoma (ILC) is the second most common histotype of breast cancer, the prognostic implications of its clinico-pathologic characteristics remain controversial. METHODS. The authors undertook a retrospective analysis of a large series of cases treated and followed at a single institution, with the objective of assessing the prognostic/predictive value of distinct clinicopathologic features of the tumors, after revision of the original histopathologic preparations and statistical analyses. RESULTS. Overall, 530 patients with pure ILC (57% with the classic type; 19% with the alveolar type; 11% with the solid type; and the remaining 13% characterized by pleomorphic, signet ring cell, histiocytoid, or apocrine features) were included in the study. Tumor size, lymph node metastatic involvement, and hormonal status were confirmed to be significant prognostic factors. In addition, statistically significant correlations were demonstrated between the 'classic' histotype of ILC and a lower risk of axillary lymph node metastases (P 5 .0005), a reduced number of metastatic lymph nodes (P 5 .04), and lower tumor grade (P
AB - BACKGROUND. Although invasive lobular carcinoma (ILC) is the second most common histotype of breast cancer, the prognostic implications of its clinico-pathologic characteristics remain controversial. METHODS. The authors undertook a retrospective analysis of a large series of cases treated and followed at a single institution, with the objective of assessing the prognostic/predictive value of distinct clinicopathologic features of the tumors, after revision of the original histopathologic preparations and statistical analyses. RESULTS. Overall, 530 patients with pure ILC (57% with the classic type; 19% with the alveolar type; 11% with the solid type; and the remaining 13% characterized by pleomorphic, signet ring cell, histiocytoid, or apocrine features) were included in the study. Tumor size, lymph node metastatic involvement, and hormonal status were confirmed to be significant prognostic factors. In addition, statistically significant correlations were demonstrated between the 'classic' histotype of ILC and a lower risk of axillary lymph node metastases (P 5 .0005), a reduced number of metastatic lymph nodes (P 5 .04), and lower tumor grade (P
KW - Breast
KW - Breast cancer
KW - Infiltrating lobular carcinoma
KW - Prognosis
KW - Special type
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U2 - 10.1002/cncr.23811
DO - 10.1002/cncr.23811
M3 - Article
C2 - 18704988
AN - SCOPUS:54049140376
VL - 113
SP - 1511
EP - 1520
JO - Cancer
JF - Cancer
SN - 0008-543X
IS - 7
ER -