Clinicopathological and immunohistochemical characteristics in male breast cancer: A retrospective case series

Giovanna Masci, Michele Caruso, Francesco Caruso, Piermario Salvini, Carlo Carnaghi, Laura Giordano, Vittoria Miserocchi, Agnese Losurdo, Monica Zuradelli, Rosalba Torrisi, Luca Di Tommaso, Corrado Tinterri, Alberto Testori, Carlos A. Garcia-Etienne, Wolfgang Gatzemeier, Armando Santoro

Research output: Contribution to journalArticlepeer-review


Back ground. Due to its rarity, male breast cancer (mBC) remains an inadequately characterized disease, and current evidence for treatment derives from female breast cancer (FBC). Methods. We retrospectively analyzed the clinic opathological characteristics, treatment patterns, and outcomes of mBCs treated from 2000 to 2013. Results. From a total of 97 patients with mBC, 6 (6.2%) with ductal in situ carcinoma were excluded, and 91 patients with invasive carcinoma were analyzed. Median age was 65 years (range: 25-87 years). Estrogen receptors were positive in 88 patients (96.7%), and progesterone receptors were positive in 84 patients (92.3%). HER-2 was over expressed in 13 of 85 patients (16%). Median follow-up was 51.5 months (range: 0.5-219.3 months). Five-year progression-free survival (PFS) was 50%, whereas overall survival (OS) was 68.1%. Patients with grades 1 and 2 presented 5-year PFS of 71% versus 22.5% for patients with grade 3 disease; 5-year OS was 85.7% for patients with grades 1 and 2 versus 53.3% of patients with grade 3. Ki-67 score >20% and adjuvant chemotherapy were also statistically significant for OS on univariate analyses. Twenty-six of 87 patients (29.8%) experienced recurrent disease and 16 of 91 patients (17.6%) developed a second neoplasia. Conclusion. Male breast cancer shows different biological patterns compared with FBC, with higher positive hormone-receptor status and lower HER-2 over expression. Grade 3 and Ki-67 >20% were associated with shorter OS.

Original languageEnglish
Pages (from-to)586-592
Number of pages7
JournalThe oncologist
Issue number6
Publication statusPublished - 2015


  • Breast neoplasm
  • Clinic opathological features
  • HER-2 expression
  • Ki-67 index
  • Male breast cancer

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


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