Clinicopathological consultation: Sinonasal malignant lymphomas: A distinct clinicopathological category

Rachel W. Vidal, Kenneth Devaney, Alessandra Rinaldo, Alfio Ferlito, Antonino Carbone

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

Sinonasal lymphomas represent a distinct subset of extranodal head and neck lymphomas. While sinonasal lymphomas are relatively rare in Western countries, in Asian populations they are the second most frequent group of extranodal lymphomas, after gastrointestinal lymphomas. With advances in immunohistochemistry, these lymphomas have been separated into B-cell, T- cell, and most recently into natural killer (NK) cell phenotypes. The B-cell phenotype is typically located in the paranasal sinuses and has a slight predominance in Western countries. The T/NK-cell phenotype is the most common in Asian and South American countries. These tumors are typically located in the nasal cavity and have an aggressive, angioinvasive growth pattern that often results in necrosis and bony erosion. Thus, sinonasal lymphomas have been included in the past with other destructive malignant and benign lesions under the descriptive and nonspecific name lethal midline granuloma. Patients are classically in the sixth to eighth decades, with a 2:1 male-to-female ratio. The prognosis is generally better than that of nodal-based lymphomas of similar histologic grade. Treatment is a combination of local irradiation and chemotherapy with an anthracycline-based regimen.

Original languageEnglish
Pages (from-to)411-419
Number of pages9
JournalAnnals of Otology, Rhinology and Laryngology
Volume108
Issue number4 I
Publication statusPublished - 1999

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Lymphoma
Referral and Consultation
Phenotype
Lethal Midline Granuloma
B-Lymphocytes
Natural Killer T-Cells
Asian Americans
Paranasal Sinuses
Nasal Cavity
Anthracyclines
Natural Killer Cells
Names
Necrosis
Neck
Immunohistochemistry
Head
T-Lymphocytes
Drug Therapy
Growth
Population

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Clinicopathological consultation : Sinonasal malignant lymphomas: A distinct clinicopathological category. / Vidal, Rachel W.; Devaney, Kenneth; Rinaldo, Alessandra; Ferlito, Alfio; Carbone, Antonino.

In: Annals of Otology, Rhinology and Laryngology, Vol. 108, No. 4 I, 1999, p. 411-419.

Research output: Contribution to journalArticle

Vidal, RW, Devaney, K, Rinaldo, A, Ferlito, A & Carbone, A 1999, 'Clinicopathological consultation: Sinonasal malignant lymphomas: A distinct clinicopathological category', Annals of Otology, Rhinology and Laryngology, vol. 108, no. 4 I, pp. 411-419.
Vidal, Rachel W. ; Devaney, Kenneth ; Rinaldo, Alessandra ; Ferlito, Alfio ; Carbone, Antonino. / Clinicopathological consultation : Sinonasal malignant lymphomas: A distinct clinicopathological category. In: Annals of Otology, Rhinology and Laryngology. 1999 ; Vol. 108, No. 4 I. pp. 411-419.
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