Clinicopathological features of pancreatic endocrine tumors: A prospective multicenter study in italy of 297 sporadic cases

Alessandro Zerbi, Massimo Falconi, Guido Rindi, Gianfranco Delle Fave, Paola Tomassetti, Claudio Pasquali, Vanessa Capitanio, Letizia Boninsegna, Valerio Di Carlo

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Objectives: Information on pancreatic endocrine tumors (PETs) comes mostly from small, retrospective, uncontrolled studies conducted on highly selected patients. The aim of the study was to describe the clinical and pathological features of PETs in a prospective, multicenter study.Methods: Newly diagnosed, histologically proven, sporadic PETs observed from June 2004 to March 2007 in 24 Italian centers were included in a specific data set.Results: Two hundred ninety-seven patients (mean age 58.614.7 years, females 51.2%, males 48.8%) were analyzed. In 73 cases (24.6%), the tumor was functioning (F) (53 insulinomas, 15 gastrinomas, 5 other syndromes) and in 232 (75.4%) it was non-functioning (NF); in 115 cases (38.7%), the diagnosis was incidental. The median tumor size was 20 mm (range 2-150). NF-PETs were significantly more represented among carcinomas (P0.001). Nodal and liver metastases were detected in 84 (28.3%) and 85 (28.6%) cases, respectively. The presence of liver metastases was significantly higher in the NF-PETs than in the F-PETs (32.1% vs. 17.8%; P0.05), and in the symptomatic than in the asymptomatic patients (34.6% vs. 19.1%; P

Original languageEnglish
Pages (from-to)1421-1429
Number of pages9
JournalAmerican Journal of Gastroenterology
Issue number6
Publication statusPublished - Jun 2010


ASJC Scopus subject areas

  • Gastroenterology

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