CLIPI: A new prognostic index for indolent cutaneous B cell lymphoma proposed by the International Extranodal Lymphoma Study Group (IELSG 11)

Michael Mian, Luigi Marcheselli, Stefano Luminari, Massimo Federico, Maria Cantonetti, Andreas H. Sarris, Andrea Rossi, Alessandro Rambaldi, Marina Frontani, Liliana Devizzi, Alessandro Massimo Gianni, Mario Busetto, Emilio Berti, Giovanni Martinelli, Richard W. Tsang, Andrés J M Ferreri, Graziella Pinotti, Enrico Pogliani, Emanuele Zucca, Sergio Cortelazzo

Research output: Contribution to journalArticlepeer-review

Abstract

Indolent primary cutaneous B cell lymphomas (PCBCL) generally have a good prognosis, but they often relapse leading in some cases to extracutaneous disease and therefore, to poor survival. We developed a prognostic model to improve the therapeutic approach to these lymphomas. Two hundred and seventeen patients with diagnosis of indolent PCBCL stage IE or IIE were assessed retrospectively. The prognostic model was built to fit a Cox proportional hazard model using all the covariates affecting progression-free survival (PFS) at p<0.1 in the univariate analysis, and the final model was selected based on the Bayes Information Criteria. Elevated serum lactate dehydrogenase, morphology of the lesion (nodule vs. other), and >2 lesions were independent predictors for PFS. To each prognostic factor was assigned a value of 1. Patients were then stratified to three risk groups: score 0 (28%), low risk; score 1 (55%), intermediate risk; score 2 and 3 (17%), high risk with a 5-year PFS of 91%, 64%, and 48%, respectively (p

Original languageEnglish
Pages (from-to)401-408
Number of pages8
JournalAnnals of Hematology
Volume90
Issue number4
DOIs
Publication statusPublished - Apr 2011

Keywords

  • B cell
  • CLIPI
  • Cutaneous
  • Lymphoma
  • Prognostic index

ASJC Scopus subject areas

  • Hematology

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