CLLU1 expression distinguishes chronic lymphocytic leukemia from other mature B-cell neoplasms

Elisabeth Oppliger Leibundgut, Daniela Rogenmoser-Dissler, Dirk de Beer, Naomi A. Porret, Silvia Zibellini, Jan Dürig, Alexander Röth, Dirk Klingbiel, Gabriela M. Baerlocher

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Abstract

The distinction of CLL from other mature B-cell neoplasms, especially from leukemic forms of mantle cell lymphoma or splenic marginal zone lymphoma, can be difficult but has important prognostic and therapeutic implications. We measured CLLU1 (CLL upregulated gene1) mRNA by qPCR and found a highly significant difference between CLL and other lymphoid neoplasms (AUC 0.96, 95%CI 0.93-0.99). Based on our cut-off values we can predict CLL and other mature B-cell neoplasms with high probability (PPV 99% and 94%). Analysis of CLLU1 expression is a rapid and reliable tool that may facilitate the diagnosis of mature B-cell neoplasms especially in inconclusive cases.

Original languageEnglish
Pages (from-to)1204-1207
Number of pages4
JournalLeukemia Research
Volume36
Issue number9
DOIs
Publication statusPublished - Sep 2012

Keywords

  • CLL
  • CLLU1
  • Mature B-cell neoplasms
  • Molecular marker

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

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    Oppliger Leibundgut, E., Rogenmoser-Dissler, D., de Beer, D., Porret, N. A., Zibellini, S., Dürig, J., Röth, A., Klingbiel, D., & Baerlocher, G. M. (2012). CLLU1 expression distinguishes chronic lymphocytic leukemia from other mature B-cell neoplasms. Leukemia Research, 36(9), 1204-1207. https://doi.org/10.1016/j.leukres.2012.05.015