Clobazam in therapy-resistant patients with partial epilepsy: A double-blind placebo-controlled crossover study

D. Koeppen, A. Baruzzi, M. Capozza, P. Chauvel, J. Courjon, P. Favel, J. Harmant, H. Lorenz, F. V L Oller, G. Procaccianti, M. Rucquoy-Ponsar, C. Sallou, G. Sideri, S. Trottier, M. Weber, P. Wolf

Research output: Contribution to journalArticlepeer-review


Clobazam was compared with placebo as antiepileptic adjunct medication in 129 therapy-resistant epileptic patients who were mainly suffering from complex partial seizures. The study was performed in five European countries according to a double-blind crossover design lasting 7 months. Two treatment periods of 3 months (1 month adjustment and 2 months maintenance medication) were separated by one medication switch-over month. The difference in seizure reduction between clobazam and placebo was significant (p <0.05). Nineteen percent of patients receiving clobazam became seizure-free during the maintenance dose period. In contrast, freedom from seizures was not observed in any placebo patient. Electroencephalogram (EEG) signs, mood ratings, and global impressions also indicated therapeutic effects of clobazam in epilepsy. The most frequent adverse reactions to clobazam were drowsiness and dizziness. However, the sedative effects of clobazam seemed to be less pronounced in comparison with other benzodiazepines. The study gives evidence of the therapeutic value of clobazam as adjunct medication in therapy-resistant partial seizures. The use of clobazam as monotherapy and long-term treatment, as well as the particular seizure response pattern to clobazam, has to be further investigated.

Original languageEnglish
Pages (from-to)495-506
Number of pages12
Issue number5
Publication statusPublished - 1987

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)


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