CLOCK gene polymorphisms and quality of aging in a cohort of nonagenarians – The MUGELLO Study

Giuditta Pagliai, Francesco Sofi, Monica Dinu, Elena Sticchi, Federica Vannetti, Raffaele Molino Lova, José Marìa Ordovàs, Anna Maria Gori, Rossella Marcucci, Betti Giusti, Claudio Macchi

Research output: Contribution to journalArticle

Abstract

A total of 356 elderly subjects [257F; 88–106 years] were genotyped for three polymorphisms of the CLOCK gene by TaqMan real-time PCR approach, in order to find associations with quality of aging. Subjects homozygous for the minor allele of rs1801260 were less frequently overweight (p = 0.046), had higher fasting glucose levels (p = 0.037), better scores at the Clock Drawing Test (CDT) (p = 0.047) and worse scores at the Geriatric Depression Scale (p = 0.032). Subjects homozygous for the minor allele of rs11932595 showed higher fasting glucose levels (p = 0.044) and better scores at CDT (p = 0.030). Conversely, subjects homozygous for the minor allele of rs4580704 showed higher triglyceride (p = 0.012), and LDL-cholesterol levels (p = 0.44), and a greater adherence to the Mediterranean diet (MD) (p = 0.044). In addition, AAC, AAG, GGC and AGC (rs1801260–rs11932595–rs4580704) haplotypes were analyzed: AAG was associated with higher risk of overweight (p = 0.008), hypertriglyceridemia (p = 0.040) and hypercholesterolemia (p = 0.036); GGC with lower risk of hyperglycemia (p = 0.022), better sleep pattern (p = 0.001) and with better score at mini-mental state examination (p = 0.010); AGC with lower risk of depression (p = 0.026) and AAC with lower adherence to the MD (p = 0.028). Therefore, CLOCK gene polymorphisms let us hypothesize an involvement in the quality of aging in a cohort of nonagenarians.

Original languageEnglish
Article number1472
JournalScientific Reports
Volume9
Issue number1
DOIs
Publication statusPublished - Dec 1 2019

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Mediterranean Diet
Alleles
Fasting
Depression
Genes
Glucose
Hypertriglyceridemia
Hypercholesterolemia
Hyperglycemia
Geriatrics
LDL Cholesterol
Haplotypes
Real-Time Polymerase Chain Reaction
Sleep
Triglycerides

ASJC Scopus subject areas

  • General

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CLOCK gene polymorphisms and quality of aging in a cohort of nonagenarians – The MUGELLO Study. / Pagliai, Giuditta; Sofi, Francesco; Dinu, Monica; Sticchi, Elena; Vannetti, Federica; Molino Lova, Raffaele; Ordovàs, José Marìa; Gori, Anna Maria; Marcucci, Rossella; Giusti, Betti; Macchi, Claudio.

In: Scientific Reports, Vol. 9, No. 1, 1472, 01.12.2019.

Research output: Contribution to journalArticle

Pagliai, Giuditta ; Sofi, Francesco ; Dinu, Monica ; Sticchi, Elena ; Vannetti, Federica ; Molino Lova, Raffaele ; Ordovàs, José Marìa ; Gori, Anna Maria ; Marcucci, Rossella ; Giusti, Betti ; Macchi, Claudio. / CLOCK gene polymorphisms and quality of aging in a cohort of nonagenarians – The MUGELLO Study. In: Scientific Reports. 2019 ; Vol. 9, No. 1.
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abstract = "A total of 356 elderly subjects [257F; 88–106 years] were genotyped for three polymorphisms of the CLOCK gene by TaqMan real-time PCR approach, in order to find associations with quality of aging. Subjects homozygous for the minor allele of rs1801260 were less frequently overweight (p = 0.046), had higher fasting glucose levels (p = 0.037), better scores at the Clock Drawing Test (CDT) (p = 0.047) and worse scores at the Geriatric Depression Scale (p = 0.032). Subjects homozygous for the minor allele of rs11932595 showed higher fasting glucose levels (p = 0.044) and better scores at CDT (p = 0.030). Conversely, subjects homozygous for the minor allele of rs4580704 showed higher triglyceride (p = 0.012), and LDL-cholesterol levels (p = 0.44), and a greater adherence to the Mediterranean diet (MD) (p = 0.044). In addition, AAC, AAG, GGC and AGC (rs1801260–rs11932595–rs4580704) haplotypes were analyzed: AAG was associated with higher risk of overweight (p = 0.008), hypertriglyceridemia (p = 0.040) and hypercholesterolemia (p = 0.036); GGC with lower risk of hyperglycemia (p = 0.022), better sleep pattern (p = 0.001) and with better score at mini-mental state examination (p = 0.010); AGC with lower risk of depression (p = 0.026) and AAC with lower adherence to the MD (p = 0.028). Therefore, CLOCK gene polymorphisms let us hypothesize an involvement in the quality of aging in a cohort of nonagenarians.",
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AU - Vannetti, Federica

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AU - Ordovàs, José Marìa

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