Clodronate and hydroxychloroquine in erosive osteoarthritis: A 24-month open randomized pilot study

Gianantonio Saviola, Lul Abdi-Ali, Lorella Campostrini, Silvano Sacco, Paola Baiardi, Mariangela Manfredi, Alessandro Mannoni, Maurizio Benucci

Research output: Contribution to journalArticlepeer-review

Abstract

We evaluated the efficacy of clodronate for treating active erosive osteoarthritis of the hand and to compare it with hydroxychloroquine. Group A consisted of 24 patients treated for 24 months with clodronate 300 mg i.v. for 7 days followed by clodronate i.m. 100 mg for 14 days every 3 months. Group B comprised 14 patients treated with hydroxychloroquine 400 mg daily for 30 days followed by 200 mg daily for the next 11 months. In group A 21/24 patients completed the trial and obtained significant pain reduction (p

Original languageEnglish
Pages (from-to)256-263
Number of pages8
JournalModern Rheumatology
Volume22
Issue number2
DOIs
Publication statusPublished - Apr 2012

Keywords

  • Clodronate
  • Erosive osteoarthritis of the hand
  • Hydroxychloroquine

ASJC Scopus subject areas

  • Rheumatology

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