Clomiphene citrate, metformin or both for ovulation induction in therapy naïve women with polycystic ovary syndrome (PCOS)? A descriptive review

Stefano Palomba, Angela Falbo, Giovanni B. La Sala

Research output: Contribution to journalArticle

Abstract

Background: Early treatment for infertile women with polycystic ovary syndrome (PCOS) is likely crucial and includes mainly clomiphene citrate (CC) and metformin.Objectives: To review the literature data regarding the use of CC, metformin, or both for the treatment of infertility in anovulatory patients with PCOS.Materials and Methods: Using PubMed database, all main relevant articles studying therapy naïve patients with PCOS who received CC, metformin or both were searched, reviewed and analyzed.Main Results and Conclusions: In infertile obese PCOS patients, CC is the therapy of choice for inducing ovulation. Combining CC and metformin is not more effective than CC alone. Further studies are needed to define the best first line treatment in non-obese PCOS patients.

Original languageEnglish
Pages (from-to)30-37
Number of pages8
JournalCurrent Drug Therapy
Volume8
Issue number1
DOIs
Publication statusPublished - 2013

Fingerprint

Clomiphene
Ovulation Induction
Polycystic Ovary Syndrome
Metformin
Therapeutics
Ovulation
PubMed
Infertility
Databases

Keywords

  • Clomiphenecitrate
  • Infertility
  • Metformin
  • Ovulationinduction
  • PCOS
  • Review
  • Sterility
  • Treatment

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

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abstract = "Background: Early treatment for infertile women with polycystic ovary syndrome (PCOS) is likely crucial and includes mainly clomiphene citrate (CC) and metformin.Objectives: To review the literature data regarding the use of CC, metformin, or both for the treatment of infertility in anovulatory patients with PCOS.Materials and Methods: Using PubMed database, all main relevant articles studying therapy na{\"i}ve patients with PCOS who received CC, metformin or both were searched, reviewed and analyzed.Main Results and Conclusions: In infertile obese PCOS patients, CC is the therapy of choice for inducing ovulation. Combining CC and metformin is not more effective than CC alone. Further studies are needed to define the best first line treatment in non-obese PCOS patients.",
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AU - Falbo, Angela

AU - La Sala, Giovanni B.

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N2 - Background: Early treatment for infertile women with polycystic ovary syndrome (PCOS) is likely crucial and includes mainly clomiphene citrate (CC) and metformin.Objectives: To review the literature data regarding the use of CC, metformin, or both for the treatment of infertility in anovulatory patients with PCOS.Materials and Methods: Using PubMed database, all main relevant articles studying therapy naïve patients with PCOS who received CC, metformin or both were searched, reviewed and analyzed.Main Results and Conclusions: In infertile obese PCOS patients, CC is the therapy of choice for inducing ovulation. Combining CC and metformin is not more effective than CC alone. Further studies are needed to define the best first line treatment in non-obese PCOS patients.

AB - Background: Early treatment for infertile women with polycystic ovary syndrome (PCOS) is likely crucial and includes mainly clomiphene citrate (CC) and metformin.Objectives: To review the literature data regarding the use of CC, metformin, or both for the treatment of infertility in anovulatory patients with PCOS.Materials and Methods: Using PubMed database, all main relevant articles studying therapy naïve patients with PCOS who received CC, metformin or both were searched, reviewed and analyzed.Main Results and Conclusions: In infertile obese PCOS patients, CC is the therapy of choice for inducing ovulation. Combining CC and metformin is not more effective than CC alone. Further studies are needed to define the best first line treatment in non-obese PCOS patients.

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