Clonal analysis and in situ characterization of lymphocytes infiltrating human breast carcinomas

Theresa L. Whiteside, Sylvia Miescher, Jean Hurlimann, Lorenzo Moretta, Vladimir von Fliedner

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

T lymphocytes were isolated from tumor biopsies in 13 patients with breast carcinomas. Immunohistology with monoclonal antibodies confirmed the presence of mononuclear cell infiltrates composed primarily of T lymphocytes in all tumors studied. While the proportion of T lymphocytes expressing the T4 or the T8 surface marker varied from tumor to tumor as determined by morphometric analysis, T8+ cells were more numerous than T4+ cells in 8/12 breast tumors studied. Relatively few T cells (

Original languageEnglish
Pages (from-to)169-178
Number of pages10
JournalCancer Immunology, Immunotherapy
Volume23
Issue number3
DOIs
Publication statusPublished - Dec 1986

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Lymphocytes
Breast Neoplasms
T-Lymphocytes
CD8-Positive T-Lymphocytes
CD4-Positive T-Lymphocytes
Neoplasms
Tumor Biomarkers
Monoclonal Antibodies
Biopsy

ASJC Scopus subject areas

  • Oncology
  • Immunology
  • Cancer Research

Cite this

Clonal analysis and in situ characterization of lymphocytes infiltrating human breast carcinomas. / Whiteside, Theresa L.; Miescher, Sylvia; Hurlimann, Jean; Moretta, Lorenzo; von Fliedner, Vladimir.

In: Cancer Immunology, Immunotherapy, Vol. 23, No. 3, 12.1986, p. 169-178.

Research output: Contribution to journalArticle

Whiteside, Theresa L. ; Miescher, Sylvia ; Hurlimann, Jean ; Moretta, Lorenzo ; von Fliedner, Vladimir. / Clonal analysis and in situ characterization of lymphocytes infiltrating human breast carcinomas. In: Cancer Immunology, Immunotherapy. 1986 ; Vol. 23, No. 3. pp. 169-178.
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