Clonal analysis and in situ characterization of lymphocytes infiltrating human breast carcinomas

Theresa L. Whiteside; Sylvia Miescher; Jean Hurlimann; Lorenzo Moretta; Vladimir von Fliedner

doi:10.1007/BF00205646

Clonal analysis and in situ characterization of lymphocytes infiltrating human breast carcinomas

Theresa L. Whiteside, Sylvia Miescher, Jean Hurlimann, Lorenzo Moretta, Vladimir von Fliedner

Istituto "Giannina Gaslini"

Research output: Contribution to journal › Article › peer-review

Abstract

T lymphocytes were isolated from tumor biopsies in 13 patients with breast carcinomas. Immunohistology with monoclonal antibodies confirmed the presence of mononuclear cell infiltrates composed primarily of T lymphocytes in all tumors studied. While the proportion of T lymphocytes expressing the T4 or the T8 surface marker varied from tumor to tumor as determined by morphometric analysis, T8+ cells were more numerous than T4+ cells in 8/12 breast tumors studied. Relatively few T cells (

Original language	English
Pages (from-to)	169-178
Number of pages	10
Journal	Cancer Immunology, Immunotherapy
Volume	23
Issue number	3
DOIs	https://doi.org/10.1007/BF00205646
Publication status	Published - Dec 1986

ASJC Scopus subject areas

Oncology
Immunology
Cancer Research

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title = "Clonal analysis and in situ characterization of lymphocytes infiltrating human breast carcinomas",

abstract = "T lymphocytes were isolated from tumor biopsies in 13 patients with breast carcinomas. Immunohistology with monoclonal antibodies confirmed the presence of mononuclear cell infiltrates composed primarily of T lymphocytes in all tumors studied. While the proportion of T lymphocytes expressing the T4 or the T8 surface marker varied from tumor to tumor as determined by morphometric analysis, T8+ cells were more numerous than T4+ cells in 8/12 breast tumors studied. Relatively few T cells (",

author = "Whiteside, {Theresa L.} and Sylvia Miescher and Jean Hurlimann and Lorenzo Moretta and {von Fliedner}, Vladimir",

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