Clonal analysis of B-cell response in pemphigus course: Toward more effective therapies

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Abstract

In this issue, Hammers et al. report the first longitudinal study of B-cell responses in pemphigus vulgaris. They show persistence of the same sets of anti-desmoglein 3 (Dsg3) B-cell clones over time in two patients with active disease, suggesting that escape from tolerance is not a frequent event. In addition, the disappearance of anti-Dsg3 B-cell clones in two patients during long-term rituximab-induced remission supports the therapeutic potential of rituximab.

Original languageEnglish
Pages (from-to)651-654
Number of pages4
JournalJournal of Investigative Dermatology
Volume135
Issue number3
DOIs
Publication statusPublished - Mar 12 2015

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Clone cells
Desmoglein 3
Pemphigus
B-Lymphocytes
Cells
Clone Cells
Longitudinal Studies
Therapeutics
Rituximab

ASJC Scopus subject areas

  • Dermatology
  • Biochemistry
  • Cell Biology
  • Molecular Biology
  • Medicine(all)

Cite this

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abstract = "In this issue, Hammers et al. report the first longitudinal study of B-cell responses in pemphigus vulgaris. They show persistence of the same sets of anti-desmoglein 3 (Dsg3) B-cell clones over time in two patients with active disease, suggesting that escape from tolerance is not a frequent event. In addition, the disappearance of anti-Dsg3 B-cell clones in two patients during long-term rituximab-induced remission supports the therapeutic potential of rituximab.",
author = "{Di Zenzo}, Giovanni and Giovanna Zambruno",
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