Clonal analysis of the cytolytic T-cell response to human tumors

Andrea Anichini; Guiseppe Fossati; Giorgio Parmiani

doi:10.1016/0167-5699(87)90215-5

Clonal analysis of the cytolytic T-cell response to human tumors

Andrea Anichini, Guiseppe Fossati, Giorgio Parmiani

Fondazione IRCCS Istituto Nazionale dei Tumori

Research output: Contribution to journal › Article › peer-review

Abstract

A variety of cloning techniques are being applied to the analysis of phenotype, specificity and mechanism of action of cytolytic T cells on autologous tumor cells. Technical factors are influencing the results and interpretation of these studies but, as Andrea Anichini and colleagues show here, this analysis has revealed that the cytotoxic response can be multiclonal, mediated by multiple mechanisms and directed to different groups of determinants expressed on the same tumor cells.

Original language	English
Pages (from-to)	385-389
Number of pages	5
Journal	Immunology Today
Volume	8
Issue number	12
DOIs	https://doi.org/10.1016/0167-5699(87)90215-5
Publication status	Published - 1987

ASJC Scopus subject areas

Immunology

Access to Document

10.1016/0167-5699(87)90215-5

Cite this

@article{15a1f0d75d854542bfd78e2fcd9d356a,

title = "Clonal analysis of the cytolytic T-cell response to human tumors",

abstract = "A variety of cloning techniques are being applied to the analysis of phenotype, specificity and mechanism of action of cytolytic T cells on autologous tumor cells. Technical factors are influencing the results and interpretation of these studies but, as Andrea Anichini and colleagues show here, this analysis has revealed that the cytotoxic response can be multiclonal, mediated by multiple mechanisms and directed to different groups of determinants expressed on the same tumor cells.",

author = "Andrea Anichini and Guiseppe Fossati and Giorgio Parmiani",

year = "1987",

doi = "10.1016/0167-5699(87)90215-5",

language = "English",

volume = "8",

pages = "385--389",

journal = "Immunology Today",

issn = "0167-5699",

publisher = "Elsevier BV",

number = "12",

}

TY - JOUR

T1 - Clonal analysis of the cytolytic T-cell response to human tumors

AU - Anichini, Andrea

AU - Fossati, Guiseppe

AU - Parmiani, Giorgio

PY - 1987

Y1 - 1987

N2 - A variety of cloning techniques are being applied to the analysis of phenotype, specificity and mechanism of action of cytolytic T cells on autologous tumor cells. Technical factors are influencing the results and interpretation of these studies but, as Andrea Anichini and colleagues show here, this analysis has revealed that the cytotoxic response can be multiclonal, mediated by multiple mechanisms and directed to different groups of determinants expressed on the same tumor cells.

AB - A variety of cloning techniques are being applied to the analysis of phenotype, specificity and mechanism of action of cytolytic T cells on autologous tumor cells. Technical factors are influencing the results and interpretation of these studies but, as Andrea Anichini and colleagues show here, this analysis has revealed that the cytotoxic response can be multiclonal, mediated by multiple mechanisms and directed to different groups of determinants expressed on the same tumor cells.

UR - http://www.scopus.com/inward/record.url?scp=38249038178&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=38249038178&partnerID=8YFLogxK

U2 - 10.1016/0167-5699(87)90215-5

DO - 10.1016/0167-5699(87)90215-5

M3 - Article

AN - SCOPUS:38249038178

VL - 8

SP - 385

EP - 389

JO - Immunology Today

JF - Immunology Today

SN - 0167-5699

IS - 12

ER -

Clonal analysis of the cytolytic T-cell response to human tumors

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this