Clonal CD8 + infiltration of the skin in common variable immunodeficiency: A prelymphomatous stage?

Angelo V. Marzano, Emilio Berti, Elvio Alessi, Ruggero Caputo

Research output: Contribution to journalArticle

Abstract

Common variable immunodeficiency is a heterogeneous syndrome characterized by hypogammaglobulinemia and recurrent bacterial infections. Patients with this syndrome also have an increased incidence of autoimmune disease and malignancy, most notably lymphoproliferative disorders. The treatment for common variable immunodeficiency is supported by the use of intravenous infusion of immunoglobulins that allows for control of the disease and avoidance of recurrent opportunistic infections. This report describes a young patient having common variable immunodeficiency who presented with a clonal CD8 + lymphocytic infiltration of the skin clinically manifesting as a widespread papulonodular eruption and resolving with intravenous immunoglobulin therapy. We speculate that such a unique cutaneous presentation may represent a prelymphomatous condition because of the development of an autonomous T-suppressor/cytotoxic cell clone, possibly also responsible for the impaired immunoglobulin production.

Original languageEnglish
Pages (from-to)710-713
Number of pages4
JournalJournal of the American Academy of Dermatology
Volume44
Issue number4
DOIs
Publication statusPublished - 2001

ASJC Scopus subject areas

  • Dermatology

Fingerprint Dive into the research topics of 'Clonal CD8 + infiltration of the skin in common variable immunodeficiency: A prelymphomatous stage?'. Together they form a unique fingerprint.

  • Cite this