Clonal expansion of CD8+ BV8 T lymphocytes in bone marrow characterizes thymoma-associated B lymphopenia

Anna Maria Masci, Giovannella Palmieri, Laura Vitiello, Liliana Montella, Francesco Perna, Paola Orlandi, Gianfranco Abbate, Serafino Zappacosta, Raffaele De Palma, Luigi Racioppi

Research output: Contribution to journalArticle

Abstract

A subgroup of thymoma patients is affected by severe immunodeficiency clinically resembling an HIV infection (Good syndrome). These individuals are characterized by B lymphopenia with B-lymphopoiesis deficiency. To investigate the pathogenesis of this unique condition, we studied the T-cell repertoire in blood and bone marrow samples by heterogeneity length analysis of CDR3 beta variable regions of the T-cell receptor (spectratyping). While no alterations were found in the peripheral blood, we detected an oligoclonal population of β variable 8 (BV8) CD8+ T cells in 5 of 5 bone marrow samples. No lymphocyte expansions were found in the bone marrow of 2 thymoma patients with normal B-cell counts, 2 healthy donors, and 3 patients with diseases unrelated to thymoma. These data suggest that an immune response toward an unknown antigen is taking place in the bone marrow of B-lymphopenic thymoma patients. We propose that BV8 CD8+ T cells may play a role in the pathogenesis of this immunodeficiency syndrome.

Original languageEnglish
Pages (from-to)3106-3108
Number of pages3
JournalBlood
Volume101
Issue number8
DOIs
Publication statusPublished - Apr 15 2003

ASJC Scopus subject areas

  • Hematology

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    Maria Masci, A., Palmieri, G., Vitiello, L., Montella, L., Perna, F., Orlandi, P., Abbate, G., Zappacosta, S., De Palma, R., & Racioppi, L. (2003). Clonal expansion of CD8+ BV8 T lymphocytes in bone marrow characterizes thymoma-associated B lymphopenia. Blood, 101(8), 3106-3108. https://doi.org/10.1182/blood-2002-08-2638