Clonal origin of cells restricted to monocytic differentiation in acute nonlymphocytic leukemia

A. M. Ferraris, G. Broccia, T. Meloni, L. Canepa, M. Sessarego, G. F. Gaetani

Research output: Contribution to journalArticle

Abstract

Two patients with acute monocytic leukemia and heterozygous for the Mediterranean variant of the X-linked enzyme, glucose-6-phosphate dehydrogenase(G6PD), were investigated to determine the number and type of progenitor cells involved. Mosaicism for Mediterranean G6PD was assessed by the different rate of utilization of 2-deoxy-glucose-6-phosphate (2dG6P) by normal and Mediterranean variants of G6PD. The monocytoid blasts were found to express one type of G6PD only, indicating their clonal origin from a common progenitor cell, whereas all other hemopoietic cell populations tested expressed the heterozygous phenotype. The findings of a unique involvement of the monocytic line in two cases of acute nonlymphocytic leukemia (ANLL) represents further evidence of heterogeneity of stem cell involvement in ANLL.

Original languageEnglish
Pages (from-to)817-820
Number of pages4
JournalBlood
Volume64
Issue number4
Publication statusPublished - 1984

ASJC Scopus subject areas

  • Hematology

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    Ferraris, A. M., Broccia, G., Meloni, T., Canepa, L., Sessarego, M., & Gaetani, G. F. (1984). Clonal origin of cells restricted to monocytic differentiation in acute nonlymphocytic leukemia. Blood, 64(4), 817-820.