Clonal origin of cells restricted to monocytic differentiation in acute nonlymphocytic leukemia

A. M. Ferraris, G. Broccia, T. Meloni, L. Canepa, M. Sessarego, G. F. Gaetani

Research output: Contribution to journalArticle

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Abstract

Two patients with acute monocytic leukemia and heterozygous for the Mediterranean variant of the X-linked enzyme, glucose-6-phosphate dehydrogenase(G6PD), were investigated to determine the number and type of progenitor cells involved. Mosaicism for Mediterranean G6PD was assessed by the different rate of utilization of 2-deoxy-glucose-6-phosphate (2dG6P) by normal and Mediterranean variants of G6PD. The monocytoid blasts were found to express one type of G6PD only, indicating their clonal origin from a common progenitor cell, whereas all other hemopoietic cell populations tested expressed the heterozygous phenotype. The findings of a unique involvement of the monocytic line in two cases of acute nonlymphocytic leukemia (ANLL) represents further evidence of heterogeneity of stem cell involvement in ANLL.

Original languageEnglish
Pages (from-to)817-820
Number of pages4
JournalBlood
Volume64
Issue number4
Publication statusPublished - 1984

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Glucosephosphate Dehydrogenase
Acute Myeloid Leukemia
Stem Cells
Leukemia, Monocytic, Acute
Glucose-6-Phosphate
Mosaicism
Stem cells
Cells
Phenotype
Enzymes
Population

ASJC Scopus subject areas

  • Hematology

Cite this

Ferraris, A. M., Broccia, G., Meloni, T., Canepa, L., Sessarego, M., & Gaetani, G. F. (1984). Clonal origin of cells restricted to monocytic differentiation in acute nonlymphocytic leukemia. Blood, 64(4), 817-820.

Clonal origin of cells restricted to monocytic differentiation in acute nonlymphocytic leukemia. / Ferraris, A. M.; Broccia, G.; Meloni, T.; Canepa, L.; Sessarego, M.; Gaetani, G. F.

In: Blood, Vol. 64, No. 4, 1984, p. 817-820.

Research output: Contribution to journalArticle

Ferraris, AM, Broccia, G, Meloni, T, Canepa, L, Sessarego, M & Gaetani, GF 1984, 'Clonal origin of cells restricted to monocytic differentiation in acute nonlymphocytic leukemia', Blood, vol. 64, no. 4, pp. 817-820.
Ferraris AM, Broccia G, Meloni T, Canepa L, Sessarego M, Gaetani GF. Clonal origin of cells restricted to monocytic differentiation in acute nonlymphocytic leukemia. Blood. 1984;64(4):817-820.
Ferraris, A. M. ; Broccia, G. ; Meloni, T. ; Canepa, L. ; Sessarego, M. ; Gaetani, G. F. / Clonal origin of cells restricted to monocytic differentiation in acute nonlymphocytic leukemia. In: Blood. 1984 ; Vol. 64, No. 4. pp. 817-820.
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