Multiple numerical and structural chromosome abnormalities were found in cultured lymphocytes of four patients with Werner's syndrome. The proportion of metaphases with structural and/or numerical aberrations varied from 30 to 44% and several of them were clonal. These results confirm definitively that Werner's syndrome is a chromosome rearrangement syndrome and that these non-constitutional chromosome changes are not exclusive of cultured fibroblasts but present also in lymphocytes.
|Number of pages||4|
|Journal||Annales de Genetique|
|Publication status||Published - 1990|
- chromosome abnormalities
- chromosome breakage syndrome
- Werner's syndrome
ASJC Scopus subject areas