Clonal structural chromosomal rearrangements in lymphocytes of four patients with Werner's syndrome

S. Scappaticci, A. Forabosco, G. Borroni, G. Orecchia, M. Fraccaro

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Multiple numerical and structural chromosome abnormalities were found in cultured lymphocytes of four patients with Werner's syndrome. The proportion of metaphases with structural and/or numerical aberrations varied from 30 to 44% and several of them were clonal. These results confirm definitively that Werner's syndrome is a chromosome rearrangement syndrome and that these non-constitutional chromosome changes are not exclusive of cultured fibroblasts but present also in lymphocytes.

Original languageEnglish
Pages (from-to)5-8
Number of pages4
JournalAnnales de Genetique
Volume33
Issue number1
Publication statusPublished - 1990

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Werner Syndrome
Chromosomes
Lymphocytes
Metaphase
Chromosome Aberrations
Fibroblasts

Keywords

  • chromosome abnormalities
  • chromosome breakage syndrome
  • Werner's syndrome

ASJC Scopus subject areas

  • Genetics

Cite this

Scappaticci, S., Forabosco, A., Borroni, G., Orecchia, G., & Fraccaro, M. (1990). Clonal structural chromosomal rearrangements in lymphocytes of four patients with Werner's syndrome. Annales de Genetique, 33(1), 5-8.

Clonal structural chromosomal rearrangements in lymphocytes of four patients with Werner's syndrome. / Scappaticci, S.; Forabosco, A.; Borroni, G.; Orecchia, G.; Fraccaro, M.

In: Annales de Genetique, Vol. 33, No. 1, 1990, p. 5-8.

Research output: Contribution to journalArticle

Scappaticci, S, Forabosco, A, Borroni, G, Orecchia, G & Fraccaro, M 1990, 'Clonal structural chromosomal rearrangements in lymphocytes of four patients with Werner's syndrome', Annales de Genetique, vol. 33, no. 1, pp. 5-8.
Scappaticci S, Forabosco A, Borroni G, Orecchia G, Fraccaro M. Clonal structural chromosomal rearrangements in lymphocytes of four patients with Werner's syndrome. Annales de Genetique. 1990;33(1):5-8.
Scappaticci, S. ; Forabosco, A. ; Borroni, G. ; Orecchia, G. ; Fraccaro, M. / Clonal structural chromosomal rearrangements in lymphocytes of four patients with Werner's syndrome. In: Annales de Genetique. 1990 ; Vol. 33, No. 1. pp. 5-8.
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