Clonal structural chromosomal rearrangements in lymphocytes of four patients with Werner's syndrome

S. Scappaticci, A. Forabosco, G. Borroni, G. Orecchia, M. Fraccaro

Research output: Contribution to journalArticlepeer-review

Abstract

Multiple numerical and structural chromosome abnormalities were found in cultured lymphocytes of four patients with Werner's syndrome. The proportion of metaphases with structural and/or numerical aberrations varied from 30 to 44% and several of them were clonal. These results confirm definitively that Werner's syndrome is a chromosome rearrangement syndrome and that these non-constitutional chromosome changes are not exclusive of cultured fibroblasts but present also in lymphocytes.

Original languageEnglish
Pages (from-to)5-8
Number of pages4
JournalAnnales de Genetique
Volume33
Issue number1
Publication statusPublished - 1990

Keywords

  • chromosome abnormalities
  • chromosome breakage syndrome
  • Werner's syndrome

ASJC Scopus subject areas

  • Genetics

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