Clonal structural chromosomal rearrangements in lymphocytes of four patients with Werner's syndrome

S. Scappaticci, A. Forabosco, G. Borroni, G. Orecchia, M. Fraccaro

Research output: Contribution to journalArticle

Abstract

Multiple numerical and structural chromosome abnormalities were found in cultured lymphocytes of four patients with Werner's syndrome. The proportion of metaphases with structural and/or numerical aberrations varied from 30 to 44% and several of them were clonal. These results confirm definitively that Werner's syndrome is a chromosome rearrangement syndrome and that these non-constitutional chromosome changes are not exclusive of cultured fibroblasts but present also in lymphocytes.

Original languageEnglish
Pages (from-to)5-8
Number of pages4
JournalAnnales de Genetique
Volume33
Issue number1
Publication statusPublished - 1990

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Werner Syndrome
Chromosomes
Lymphocytes
Metaphase
Chromosome Aberrations
Fibroblasts

Keywords

  • chromosome abnormalities
  • chromosome breakage syndrome
  • Werner's syndrome

ASJC Scopus subject areas

  • Genetics

Cite this

Scappaticci, S., Forabosco, A., Borroni, G., Orecchia, G., & Fraccaro, M. (1990). Clonal structural chromosomal rearrangements in lymphocytes of four patients with Werner's syndrome. Annales de Genetique, 33(1), 5-8.

Clonal structural chromosomal rearrangements in lymphocytes of four patients with Werner's syndrome. / Scappaticci, S.; Forabosco, A.; Borroni, G.; Orecchia, G.; Fraccaro, M.

In: Annales de Genetique, Vol. 33, No. 1, 1990, p. 5-8.

Research output: Contribution to journalArticle

Scappaticci, S, Forabosco, A, Borroni, G, Orecchia, G & Fraccaro, M 1990, 'Clonal structural chromosomal rearrangements in lymphocytes of four patients with Werner's syndrome', Annales de Genetique, vol. 33, no. 1, pp. 5-8.
Scappaticci S, Forabosco A, Borroni G, Orecchia G, Fraccaro M. Clonal structural chromosomal rearrangements in lymphocytes of four patients with Werner's syndrome. Annales de Genetique. 1990;33(1):5-8.
Scappaticci, S. ; Forabosco, A. ; Borroni, G. ; Orecchia, G. ; Fraccaro, M. / Clonal structural chromosomal rearrangements in lymphocytes of four patients with Werner's syndrome. In: Annales de Genetique. 1990 ; Vol. 33, No. 1. pp. 5-8.
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