Clonazepam and vibration in restless legs syndrome

P. Montagna, L. Sassoli de Bianchi, M. Zucconi, F. Cirignotta, E. Lugaresi

Research output: Contribution to journalArticlepeer-review


There have been no controlled therapeutic trials in Restless Legs Syndrome (RLS). In 6 patients with RLS, a randomized double-blind cross-over trial vs placebo showed a significant efficacy of clonazepam in improving subjective quality of sleep and leg dysaesthesia. Vibratory stimulation of the leg showed a less pronounced and non-significant effect. Clonazepam is a safe and effective drug for treatment of RLS; however its long-term efficacy needs confirmation.

Original languageEnglish
Pages (from-to)428-430
Number of pages3
JournalActa Neurologica Scandinavica
Issue number6
Publication statusPublished - 1984

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)


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