Clonidine-induced place preference is mediated by α2-adrenoceptors outside the locus coeruleus

Luigi Cervo, Claudia Rossi, Rosario Samanin

Research output: Contribution to journalArticlepeer-review

Abstract

Clonidine, administered intraperitoneally at doses of 0.05 and 0.5 mg/kg, produced a conditioned place preference when paired with the less preferred compartment. No preference for either compartment was found when a balanced conditioning place preference paradigm was used. Infusion of 6 μg/μ1 6-hydroxydopamine in the locus coeruleus, which markedly depleted noradrenaline in terminal regions, did not modify the effect of 0.05 and 0.5 mg clonidine on place preference. The effect of 0.5 mg/kg was prevented by 1 mg/kg idazoxan, an α2-adrenoceptor antagonist, but not by 3 mg/kg prazosin, which blocks α1-adrenoceptors. Idazoxan by itself (at doses from 0.3 to 3 mg/kg) induced a conditioned place preference when paired with the less preferred side. The results suggest that clonidine has motivational properties which serve to attenuate the aversiveness of the less preferred side in a conditioned place preference paradigm. Stimulation of α1-adrenoceptors postsynaptic to noradrenaline-containing neurons seems to be involved.

Original languageEnglish
Pages (from-to)201-207
Number of pages7
JournalEuropean Journal of Pharmacology
Volume238
Issue number2-3
DOIs
Publication statusPublished - Jul 20 1993

Keywords

  • (Rat)
  • Clonidine
  • preference
  • α-Adrenoceptors

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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