Clonidine inhibits IgE-mediated and IgE-independent in vitro histamine release from human basophil leukocytes

A. Miadonna, A. Tedeschi, E. Leggieri, P. Parravicini, M. Lorini, C. Zanussi

Research output: Contribution to journalArticle

Abstract

Clonidine, a common antihypertensive agent, was recently shown to inhibit antigen-induced wheal and flare reactions, as well as allergen-evoked bronchoconstriction in allergic patients. In this study we investigated the in vitro anti-allergic properties of clonidine. This α2 adrenoceptor agonist inhibited, in a dose-dependent fashion, basophil histamine secretion elicited by anti-IgE and f-met peptide; it also blocked, though to a lesser extent, the calcium ionophore A23187-induced histamine release. H2 receptor stimulation seems to be responsible for the reduction in histamine release observed, since it can be antagonized by cimetidine, but not by α1, α2 and H1 blockers.

Original languageEnglish
Pages (from-to)473-477
Number of pages5
JournalInternational Journal of Immunopharmacology
Volume11
Issue number5
DOIs
Publication statusPublished - 1989

Fingerprint

Basophils
Histamine Release
Clonidine
Immunoglobulin E
Leukocytes
Anti-Allergic Agents
Histamine H2 Receptors
Bronchoconstriction
Calcium Ionophores
Cimetidine
Calcimycin
Allergens
Adrenergic Receptors
Histamine
Antihypertensive Agents
Antigens
Peptides
In Vitro Techniques
anti-IgE antibodies

ASJC Scopus subject areas

  • Immunology
  • Pharmacology

Cite this

Clonidine inhibits IgE-mediated and IgE-independent in vitro histamine release from human basophil leukocytes. / Miadonna, A.; Tedeschi, A.; Leggieri, E.; Parravicini, P.; Lorini, M.; Zanussi, C.

In: International Journal of Immunopharmacology, Vol. 11, No. 5, 1989, p. 473-477.

Research output: Contribution to journalArticle

Miadonna, A. ; Tedeschi, A. ; Leggieri, E. ; Parravicini, P. ; Lorini, M. ; Zanussi, C. / Clonidine inhibits IgE-mediated and IgE-independent in vitro histamine release from human basophil leukocytes. In: International Journal of Immunopharmacology. 1989 ; Vol. 11, No. 5. pp. 473-477.
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