Clonidine Treatment of Alzheimer's Disease

Erich Mohr, Paul Fedio, Jerry Schlegel, Giovanni Fabbrini, Jill Williams, M. Maral Mouradian, Ulrike M. Mann, Jules J. Claus, Thomas N. Chase

Research output: Contribution to journalArticlepeer-review


A loss of cortical noradrenergic innervation may contribute to the intellectual deterioration in Alzheimer's disease. To test the hypothesis that noradrenergic replacement may confer symptomatic benefit, a double-blind, placebo-controlled therapeutic trial with clonidine hydrochloride (Catapres), a centrally active noradrenergic receptor agonist, was undertaken in eight patients with the clinical diagnosis of Alzheimer's disease. No statistically significant changes in cognitive function were found over a range of doses, including those that produced clinically observable side effects. These preliminary results indicate a need for alternative noradrenergic replacement strategies in Alzheimer's disease.

Original languageEnglish
Pages (from-to)376-378
Number of pages3
JournalArchives of Neurology
Issue number4
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology
  • Neuroscience(all)


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