Cloning and functional analysis of the allelic polymorphism in the transcription regulatory region of interleukin-1α

Roberto Dominici, Monica Cattaneo, Giulia Malferrari, Davide Archi, Claudio Mariani, Luigi Grimaldi, Ida Biunno

Research output: Contribution to journalArticlepeer-review

Abstract

A strong correlation between the TT-889 genotype over CC-889 of the interleukin-1α (IL-1α) transcription regulatory region and age of Alzheimer's disease onset has recently been reported. To determine the functional effects of the genetic variants on plasma protein levels, we cloned the promoter region and determined its activity. The TT genotype significantly increased the transcriptional activity of the IL-1α gene with respect to the CC genotype. A slight increase of the IL-1α mRNA and protein levels was also observed in the plasma.

Original languageEnglish
Pages (from-to)82-86
Number of pages5
JournalImmunogenetics
Volume54
Issue number2
DOIs
Publication statusPublished - 2002

Keywords

  • Allelic polymorphism
  • Functional analysis
  • Interleukin-1α promoter

ASJC Scopus subject areas

  • Immunology
  • Genetics

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