Cloning and mapping of the mouse α7-neuronal nicotinic acetylcholine receptor

Avi Orr-Urtreger, Michael F. Seldin, Antonio Baldini, Arthur L. Beaudet

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

We report the isolation of cDNA clones for the mouse α7 neuronal nicotinic acetylcholine receptor subunit (gene symbol Acra7), the only nicotinic receptor subunit known to bind α-bungarotoxin in mammalian brain. This gene may have relevance to nicotine sensitivity and to some electrophysiologic findings in schizophrenia. The mouse α7 subunit gene encodes a protein of 502 amino acids with substantial identity to the rat (99.6%), human (92.8%), and chicken (87.5%) amino acid sequences. The α7 gene was mapped to mouse chromosome 7 near the p locus with the following gene order from proximal to distal: Myod1-3.5 ± 1.7 cM-Gas2-0.9 cM ± 0.9 cM-D7Mit70-1.8 ± 1.2 cM- Acra7-4.4 ± 1.0 cM-Hras1-ps1/Igf1r/Snrp2a. The human gene was confirmed to map to the homologous region of human chromosome 15q13-q14.

Original languageEnglish
Pages (from-to)399-402
Number of pages4
JournalGenomics
Volume26
Issue number2
DOIs
Publication statusPublished - Mar 20 1995

Fingerprint

Nicotinic Receptors
Organism Cloning
Genes
Bungarotoxins
Chromosomes, Human, Pair 7
Gene Order
Human Chromosomes
Nicotine
Amino Acid Sequence
Chickens
Schizophrenia
Complementary DNA
Clone Cells
Amino Acids
Brain
Proteins

ASJC Scopus subject areas

  • Genetics

Cite this

Orr-Urtreger, A., Seldin, M. F., Baldini, A., & Beaudet, A. L. (1995). Cloning and mapping of the mouse α7-neuronal nicotinic acetylcholine receptor. Genomics, 26(2), 399-402. https://doi.org/10.1016/0888-7543(95)80228-E

Cloning and mapping of the mouse α7-neuronal nicotinic acetylcholine receptor. / Orr-Urtreger, Avi; Seldin, Michael F.; Baldini, Antonio; Beaudet, Arthur L.

In: Genomics, Vol. 26, No. 2, 20.03.1995, p. 399-402.

Research output: Contribution to journalArticle

Orr-Urtreger, A, Seldin, MF, Baldini, A & Beaudet, AL 1995, 'Cloning and mapping of the mouse α7-neuronal nicotinic acetylcholine receptor', Genomics, vol. 26, no. 2, pp. 399-402. https://doi.org/10.1016/0888-7543(95)80228-E
Orr-Urtreger, Avi ; Seldin, Michael F. ; Baldini, Antonio ; Beaudet, Arthur L. / Cloning and mapping of the mouse α7-neuronal nicotinic acetylcholine receptor. In: Genomics. 1995 ; Vol. 26, No. 2. pp. 399-402.
@article{97c17302b844418b8ba84dca6ca20f48,
title = "Cloning and mapping of the mouse α7-neuronal nicotinic acetylcholine receptor",
abstract = "We report the isolation of cDNA clones for the mouse α7 neuronal nicotinic acetylcholine receptor subunit (gene symbol Acra7), the only nicotinic receptor subunit known to bind α-bungarotoxin in mammalian brain. This gene may have relevance to nicotine sensitivity and to some electrophysiologic findings in schizophrenia. The mouse α7 subunit gene encodes a protein of 502 amino acids with substantial identity to the rat (99.6{\%}), human (92.8{\%}), and chicken (87.5{\%}) amino acid sequences. The α7 gene was mapped to mouse chromosome 7 near the p locus with the following gene order from proximal to distal: Myod1-3.5 ± 1.7 cM-Gas2-0.9 cM ± 0.9 cM-D7Mit70-1.8 ± 1.2 cM- Acra7-4.4 ± 1.0 cM-Hras1-ps1/Igf1r/Snrp2a. The human gene was confirmed to map to the homologous region of human chromosome 15q13-q14.",
author = "Avi Orr-Urtreger and Seldin, {Michael F.} and Antonio Baldini and Beaudet, {Arthur L.}",
year = "1995",
month = "3",
day = "20",
doi = "10.1016/0888-7543(95)80228-E",
language = "English",
volume = "26",
pages = "399--402",
journal = "Genomics",
issn = "0888-7543",
publisher = "Academic Press Inc.",
number = "2",

}

TY - JOUR

T1 - Cloning and mapping of the mouse α7-neuronal nicotinic acetylcholine receptor

AU - Orr-Urtreger, Avi

AU - Seldin, Michael F.

AU - Baldini, Antonio

AU - Beaudet, Arthur L.

PY - 1995/3/20

Y1 - 1995/3/20

N2 - We report the isolation of cDNA clones for the mouse α7 neuronal nicotinic acetylcholine receptor subunit (gene symbol Acra7), the only nicotinic receptor subunit known to bind α-bungarotoxin in mammalian brain. This gene may have relevance to nicotine sensitivity and to some electrophysiologic findings in schizophrenia. The mouse α7 subunit gene encodes a protein of 502 amino acids with substantial identity to the rat (99.6%), human (92.8%), and chicken (87.5%) amino acid sequences. The α7 gene was mapped to mouse chromosome 7 near the p locus with the following gene order from proximal to distal: Myod1-3.5 ± 1.7 cM-Gas2-0.9 cM ± 0.9 cM-D7Mit70-1.8 ± 1.2 cM- Acra7-4.4 ± 1.0 cM-Hras1-ps1/Igf1r/Snrp2a. The human gene was confirmed to map to the homologous region of human chromosome 15q13-q14.

AB - We report the isolation of cDNA clones for the mouse α7 neuronal nicotinic acetylcholine receptor subunit (gene symbol Acra7), the only nicotinic receptor subunit known to bind α-bungarotoxin in mammalian brain. This gene may have relevance to nicotine sensitivity and to some electrophysiologic findings in schizophrenia. The mouse α7 subunit gene encodes a protein of 502 amino acids with substantial identity to the rat (99.6%), human (92.8%), and chicken (87.5%) amino acid sequences. The α7 gene was mapped to mouse chromosome 7 near the p locus with the following gene order from proximal to distal: Myod1-3.5 ± 1.7 cM-Gas2-0.9 cM ± 0.9 cM-D7Mit70-1.8 ± 1.2 cM- Acra7-4.4 ± 1.0 cM-Hras1-ps1/Igf1r/Snrp2a. The human gene was confirmed to map to the homologous region of human chromosome 15q13-q14.

UR - http://www.scopus.com/inward/record.url?scp=0028905884&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028905884&partnerID=8YFLogxK

U2 - 10.1016/0888-7543(95)80228-E

DO - 10.1016/0888-7543(95)80228-E

M3 - Article

VL - 26

SP - 399

EP - 402

JO - Genomics

JF - Genomics

SN - 0888-7543

IS - 2

ER -