Cloning and mapping of the mouse α7-neuronal nicotinic acetylcholine receptor

Avi Orr-Urtreger, Michael F. Seldin, Antonio Baldini, Arthur L. Beaudet

Research output: Contribution to journalArticlepeer-review

Abstract

We report the isolation of cDNA clones for the mouse α7 neuronal nicotinic acetylcholine receptor subunit (gene symbol Acra7), the only nicotinic receptor subunit known to bind α-bungarotoxin in mammalian brain. This gene may have relevance to nicotine sensitivity and to some electrophysiologic findings in schizophrenia. The mouse α7 subunit gene encodes a protein of 502 amino acids with substantial identity to the rat (99.6%), human (92.8%), and chicken (87.5%) amino acid sequences. The α7 gene was mapped to mouse chromosome 7 near the p locus with the following gene order from proximal to distal: Myod1-3.5 ± 1.7 cM-Gas2-0.9 cM ± 0.9 cM-D7Mit70-1.8 ± 1.2 cM- Acra7-4.4 ± 1.0 cM-Hras1-ps1/Igf1r/Snrp2a. The human gene was confirmed to map to the homologous region of human chromosome 15q13-q14.

Original languageEnglish
Pages (from-to)399-402
Number of pages4
JournalGenomics
Volume26
Issue number2
DOIs
Publication statusPublished - Mar 20 1995

ASJC Scopus subject areas

  • Genetics

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