Cloning and molecular characterization of three ubiquitin fusion degradation 1 (Ufd1) ortholog genes from Xenopus laevis, Gallus gallus and Drosophila melanogaster

A. Ratti, F. Amati, M. Bozzali, E. Conti, F. Sangiuolo, M. Berloco, G. Palumbo, A. Botta, A. Pizzuti, Giuseppe Novelli, B. Dallapiccola

Research output: Contribution to journalArticlepeer-review

Abstract

The yeast ubiquitin fusion degradation 1 (Ufd1) protein is involved in a degradation pathway for ubiquitin fused products. The human ortholog gene (UFD1-like, UFD1L) is deleted in patients affected by the DiGeorge/velocardiofacial syndromes. We report the cloning of UFD1L orthologs from Drosophila melanogaster (dufd1l), Xenopus laevis and Gallus gallus. The 1,125-bp Drosophila cDNA encodes a protein of 316 amino acids, showing 60% identity with the human and murine proteins. The identity to the G. gallus, X. laevis, C. elegans and S. cerevisiae proteins is 95%, 83%, 32%, and 36%, respectively. Northern expression data in Drosophila indicate that dufd1l is expressed through embryonic, larval and pupal development, as well as in the adult fly.

Original languageEnglish
Pages (from-to)279-282
Number of pages4
JournalCytogenetics and Cell Genetics
Volume92
Issue number3-4
Publication statusPublished - 2001

ASJC Scopus subject areas

  • Genetics
  • Cell Biology

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