TY - JOUR
T1 - Cloning of a new gene (FB19) within HLA class I region
AU - Totaro, Angela
AU - Grifa, Anna
AU - Carella, Massimo
AU - Rommens, Johanna M.
AU - Valentino, Maria A.
AU - Roetto, Antonella
AU - Zelante, Leopoldo
AU - Gasparini, Paolo
PY - 1998/9/29
Y1 - 1998/9/29
N2 - A novel gene (named FB19) has been identified within the HLA class I region at human chromosome 6p21.3. A 4.5-kb cDNA containing a 2820-bp open reading frame for a predicted protein of 940 aa was identified. No homology with known gene was detected at the DNA level, while the predicted protein is characterized by a glycine-rich region followed by a domain of 35 residues that shows high homology with the CAT56 gene, another gene of MHC class I. A 4.5-kb transcript was detected in several tissues and cell lines, clearly indicating a wide distribution of expression. Once its function is defined, it could be possible to investigate the relationship between the FB19 gene and the several diseases already mapped within the HLA class I region.
AB - A novel gene (named FB19) has been identified within the HLA class I region at human chromosome 6p21.3. A 4.5-kb cDNA containing a 2820-bp open reading frame for a predicted protein of 940 aa was identified. No homology with known gene was detected at the DNA level, while the predicted protein is characterized by a glycine-rich region followed by a domain of 35 residues that shows high homology with the CAT56 gene, another gene of MHC class I. A 4.5-kb transcript was detected in several tissues and cell lines, clearly indicating a wide distribution of expression. Once its function is defined, it could be possible to investigate the relationship between the FB19 gene and the several diseases already mapped within the HLA class I region.
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U2 - 10.1006/bbrc.1998.9354
DO - 10.1006/bbrc.1998.9354
M3 - Article
C2 - 9784381
AN - SCOPUS:0032578617
VL - 250
SP - 555
EP - 557
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
SN - 0006-291X
IS - 3
ER -