Clopidogrel non-responsiveness and risk of cardiovascular morbidity: An updated meta-analysis

Francesco Sofi, Rossella Marcucci, Anna Maria Gori, Betti Giusti, Rosanna Abbate, Gian Franco Gensini

Research output: Contribution to journalArticlepeer-review

Abstract

We performed this meta-analysis to update the clinical evidences on the relation between clopidogrel non-responsiveness and clinical outcomes in patients with coronary artery disease (CAD) who underwent percutaneous coronary intervention. An electronic literature search through MEDLINE, EMBASE, Web of Science, and the Cochrane Library and bibliographies of retrieved articles up to January, 2009 was conducted. Studies were included if they had a cohort prospective design, if they analysed clopidogrel responsiveness in CAD patients in relation to death and/or occurrence of adverse coronary events during followup, and if they reported an adequate statistical analysis. Fourteen studies, totalling 4,564 CAD patients followed for a time ranging from 14 days to one year, were included. The cumulative analysis reported that residual platelet reactivity despite clopidogrel treatment was significantly associated with an increased risk of death and/or thrombotic recurrences (odds ratio [OR] 5.67, 95% confidence interval [CI] 2.97 to 10.84; p

Original languageEnglish
Pages (from-to)841-848
Number of pages8
JournalThrombosis and Haemostasis
Volume103
Issue number4
DOIs
Publication statusPublished - Apr 2010

Keywords

  • Antiplatelet therapy
  • Clinical recurrences
  • Clopidogrel
  • Meta-analysis

ASJC Scopus subject areas

  • Hematology

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