Abstract
We report that cloricromene (5-30 μM) inhibited thrombin-induced platelet aggregation and synergized with other antiplatelet compounds. The antiaggregatory effect of subthreshold concentrations of the prostaglandin (PG)I2 analogue, iloprost (0.2 nM), or of sodium nitroprusside (1 μm), acting through a nitric oxide (NO)-like mechanism, was significantly potentiated by co-incubation with cloricromene (5 μM). In addition, cloricromene enhanced the antiplatelet activity of the NO-like factor released by peritoneal rat polymorphonuclear cells. Thus, the present results show that cloricromene possesses direct antiplatelet properties and synergizes with other endogenous as well as exogenous antiplatelet compounds.
| Original language | English |
|---|---|
| Pages (from-to) | 181-184 |
| Number of pages | 4 |
| Journal | European Journal of Pharmacology |
| Volume | 222 |
| Issue number | 2-3 |
| DOIs | |
| Publication status | Published - Nov 10 1992 |
Keywords
- Antiplatelet compounds
- Cloricromene
- Platelet aggregation
- Polymorphonuclear cells
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience
- Pharmacology
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Cite this
Mollace, V., Prosdocimi, M., & Nisticó, G. (1992). Cloricromene synergizes with antiplatelet drugs and nitric oxide-like factor derived from rat peritoneal polymorphonuclear cells. European Journal of Pharmacology, 222(2-3), 181-184. https://doi.org/10.1016/0014-2999(92)90853-V