TY - JOUR
T1 - Cloricromene synergizes with antiplatelet drugs and nitric oxide-like factor derived from rat peritoneal polymorphonuclear cells
AU - Mollace, Vincenzo
AU - Prosdocimi, Marco
AU - Nisticó, Giuseppe
PY - 1992/11/10
Y1 - 1992/11/10
N2 - We report that cloricromene (5-30 μM) inhibited thrombin-induced platelet aggregation and synergized with other antiplatelet compounds. The antiaggregatory effect of subthreshold concentrations of the prostaglandin (PG)I2 analogue, iloprost (0.2 nM), or of sodium nitroprusside (1 μm), acting through a nitric oxide (NO)-like mechanism, was significantly potentiated by co-incubation with cloricromene (5 μM). In addition, cloricromene enhanced the antiplatelet activity of the NO-like factor released by peritoneal rat polymorphonuclear cells. Thus, the present results show that cloricromene possesses direct antiplatelet properties and synergizes with other endogenous as well as exogenous antiplatelet compounds.
AB - We report that cloricromene (5-30 μM) inhibited thrombin-induced platelet aggregation and synergized with other antiplatelet compounds. The antiaggregatory effect of subthreshold concentrations of the prostaglandin (PG)I2 analogue, iloprost (0.2 nM), or of sodium nitroprusside (1 μm), acting through a nitric oxide (NO)-like mechanism, was significantly potentiated by co-incubation with cloricromene (5 μM). In addition, cloricromene enhanced the antiplatelet activity of the NO-like factor released by peritoneal rat polymorphonuclear cells. Thus, the present results show that cloricromene possesses direct antiplatelet properties and synergizes with other endogenous as well as exogenous antiplatelet compounds.
KW - Antiplatelet compounds
KW - Cloricromene
KW - Platelet aggregation
KW - Polymorphonuclear cells
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U2 - 10.1016/0014-2999(92)90853-V
DO - 10.1016/0014-2999(92)90853-V
M3 - Article
C2 - 1280590
AN - SCOPUS:0026458141
VL - 222
SP - 181
EP - 184
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
SN - 0014-2999
IS - 2-3
ER -