Cloricromene synergizes with antiplatelet drugs and nitric oxide-like factor derived from rat peritoneal polymorphonuclear cells

Vincenzo Mollace, Marco Prosdocimi, Giuseppe Nisticó

Research output: Contribution to journalArticle

Abstract

We report that cloricromene (5-30 μM) inhibited thrombin-induced platelet aggregation and synergized with other antiplatelet compounds. The antiaggregatory effect of subthreshold concentrations of the prostaglandin (PG)I2 analogue, iloprost (0.2 nM), or of sodium nitroprusside (1 μm), acting through a nitric oxide (NO)-like mechanism, was significantly potentiated by co-incubation with cloricromene (5 μM). In addition, cloricromene enhanced the antiplatelet activity of the NO-like factor released by peritoneal rat polymorphonuclear cells. Thus, the present results show that cloricromene possesses direct antiplatelet properties and synergizes with other endogenous as well as exogenous antiplatelet compounds.

Original languageEnglish
Pages (from-to)181-184
Number of pages4
JournalEuropean Journal of Pharmacology
Volume222
Issue number2-3
DOIs
Publication statusPublished - Nov 10 1992

Keywords

  • Antiplatelet compounds
  • Cloricromene
  • Platelet aggregation
  • Polymorphonuclear cells

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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