Cloricromene synergizes with antiplatelet drugs and nitric oxide-like factor derived from rat peritoneal polymorphonuclear cells

Vincenzo Mollace; Marco Prosdocimi; Giuseppe Nisticó

doi:10.1016/0014-2999(92)90853-V

Cloricromene synergizes with antiplatelet drugs and nitric oxide-like factor derived from rat peritoneal polymorphonuclear cells

Vincenzo Mollace, Marco Prosdocimi, Giuseppe Nisticó

Istituto San Raffaele Pisana

Research output: Contribution to journal › Article › peer-review

Abstract

We report that cloricromene (5-30 μM) inhibited thrombin-induced platelet aggregation and synergized with other antiplatelet compounds. The antiaggregatory effect of subthreshold concentrations of the prostaglandin (PG)I₂ analogue, iloprost (0.2 nM), or of sodium nitroprusside (1 μm), acting through a nitric oxide (NO)-like mechanism, was significantly potentiated by co-incubation with cloricromene (5 μM). In addition, cloricromene enhanced the antiplatelet activity of the NO-like factor released by peritoneal rat polymorphonuclear cells. Thus, the present results show that cloricromene possesses direct antiplatelet properties and synergizes with other endogenous as well as exogenous antiplatelet compounds.

Original language	English
Pages (from-to)	181-184
Number of pages	4
Journal	European Journal of Pharmacology
Volume	222
Issue number	2-3
DOIs	https://doi.org/10.1016/0014-2999(92)90853-V
Publication status	Published - Nov 10 1992

Keywords

Antiplatelet compounds
Cloricromene
Platelet aggregation
Polymorphonuclear cells

ASJC Scopus subject areas

Cellular and Molecular Neuroscience
Pharmacology

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10.1016/0014-2999(92)90853-V

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title = "Cloricromene synergizes with antiplatelet drugs and nitric oxide-like factor derived from rat peritoneal polymorphonuclear cells",

abstract = "We report that cloricromene (5-30 μM) inhibited thrombin-induced platelet aggregation and synergized with other antiplatelet compounds. The antiaggregatory effect of subthreshold concentrations of the prostaglandin (PG)I2 analogue, iloprost (0.2 nM), or of sodium nitroprusside (1 μm), acting through a nitric oxide (NO)-like mechanism, was significantly potentiated by co-incubation with cloricromene (5 μM). In addition, cloricromene enhanced the antiplatelet activity of the NO-like factor released by peritoneal rat polymorphonuclear cells. Thus, the present results show that cloricromene possesses direct antiplatelet properties and synergizes with other endogenous as well as exogenous antiplatelet compounds.",

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T1 - Cloricromene synergizes with antiplatelet drugs and nitric oxide-like factor derived from rat peritoneal polymorphonuclear cells

AU - Mollace, Vincenzo

AU - Prosdocimi, Marco

AU - Nisticó, Giuseppe

PY - 1992/11/10

Y1 - 1992/11/10

N2 - We report that cloricromene (5-30 μM) inhibited thrombin-induced platelet aggregation and synergized with other antiplatelet compounds. The antiaggregatory effect of subthreshold concentrations of the prostaglandin (PG)I2 analogue, iloprost (0.2 nM), or of sodium nitroprusside (1 μm), acting through a nitric oxide (NO)-like mechanism, was significantly potentiated by co-incubation with cloricromene (5 μM). In addition, cloricromene enhanced the antiplatelet activity of the NO-like factor released by peritoneal rat polymorphonuclear cells. Thus, the present results show that cloricromene possesses direct antiplatelet properties and synergizes with other endogenous as well as exogenous antiplatelet compounds.

AB - We report that cloricromene (5-30 μM) inhibited thrombin-induced platelet aggregation and synergized with other antiplatelet compounds. The antiaggregatory effect of subthreshold concentrations of the prostaglandin (PG)I2 analogue, iloprost (0.2 nM), or of sodium nitroprusside (1 μm), acting through a nitric oxide (NO)-like mechanism, was significantly potentiated by co-incubation with cloricromene (5 μM). In addition, cloricromene enhanced the antiplatelet activity of the NO-like factor released by peritoneal rat polymorphonuclear cells. Thus, the present results show that cloricromene possesses direct antiplatelet properties and synergizes with other endogenous as well as exogenous antiplatelet compounds.

KW - Antiplatelet compounds

KW - Cloricromene

KW - Platelet aggregation

KW - Polymorphonuclear cells

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Cloricromene synergizes with antiplatelet drugs and nitric oxide-like factor derived from rat peritoneal polymorphonuclear cells

Abstract

Keywords

ASJC Scopus subject areas

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