Close association between antibodies to gytoskeletal intermediate filaments, and chronic graft-versus-host disease

Pier Luigi Tazzari, Marco Gobbi, Daniela Zauli, Angela Tassinari, Cristina Crespi, Fabio Miserocchi, Angelo Dinota, Giuseppe Bambini, Paolo Rica, Sante Tura

Research output: Contribution to journalArticlepeer-review

Abstract

Chronic graft-versus-host disease can mimic various autoimmune disorders, although autoantibodies are rarely detected in the sera of affected patients. Antibodies to cytcskeleton are a frequent finding in patients affected by autoimmune disorders. In all the sera of 16 patients who were submitted to allogeneic bone marrow transplantation, we have found antibodies against cytoskeletai intermediate filaments. Moreover, the titer of such antibodies is quite elevated when compared with those reported in autoimmune disorders. A statistically significant difference between the titers found in patients without and with cGVHD (median 1:40 vs. 1:256, P

Original languageEnglish
Pages (from-to)234-236
Number of pages3
JournalTransplantation
Volume44
Issue number2
Publication statusPublished - 1987

ASJC Scopus subject areas

  • Transplantation
  • Immunology

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