Closed-loop delivery systems versus manually controlled administration of total IV Anesthesia: A meta-analysis of randomized clinical trials

L Pasin, Pasquale Nardelli, Margherita Pintaudi, M Greco, M Zambon, L Cabrini, A Zangrillo

Research output: Contribution to journalArticle


Bispectral Index Scale (BIS)-guided closed-loop delivery of anesthetics has been extensively studied. We performed a meta-analysis of all the randomized clinical trials comparing efficacy and performance between BIS-guided closed-loop delivery and manually controlled administration of total IV anesthesia. Scopus, PubMed, EMBASE, and the Cochrane Central Register of clinical trials were searched for pertinent studies. Inclusion criteria were random allocation to treatment and closed-loop delivery systems versus manually controlled administration of total IV anesthesia in any surgical setting. Exclusion criteria were duplicate publications and nonadult studies. Twelve studies were included, randomly allocating 1284 patients. Use of closed-loop anesthetic delivery systems was associated with a significant reduction in the dose of propofol administered for induction of anesthesia (mean difference [MD] = 0.37 [0.17-0.57], P for effect
Original languageEnglish
Pages (from-to)456-464
Number of pages9
JournalAnesthesia and Analgesia
Issue number2
Publication statusPublished - 2017


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