Clostridium difficile infection in children

epidemiology and risk of recurrence in a low-prevalence country

A. L O Vecchio, Laura Lancella, Claudia Tagliabue, C. de Giacomo, Silvia Garazzino, M. Mainetti, Laura Cursi, E. Borali, M. V. de Vita, Elena Boccuzzi, L. Castellazzi, Susanna Esposito, A. Guarino

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Clostridium difficile infection (CDI) is increasingly found in children worldwide, but limited data are available from children living in southern Europe. A 6-year retrospective study was performed to investigate the epidemiology, clinical features, treatment, and risk of recurrence in Italy. Data of children with community- and hospital-acquired CDI (CA-CDI and HA-CDI, respectively) seen at seven pediatric referral centers in Italy were recorded retrospectively. Annual infection rates/10,000 hospital admissions were calculated. Logistic regression was used to investigate risk factors for recurrence. A total of 177 CDI episodes was reported in 148 children (83 males, median age 55.3 months), with a cumulative infection rate of 2.25/10,000 admissions, with no significant variability over time. The majority of children (60.8 %) had CA-CDI. Children with HA-CDI (39.2 %) had a longer duration of symptoms and hospitalization (p = 0.003) and a more common previous use of antibiotics (p = 0.0001). Metronidazole was used in 70.7 % of cases (87/123) and vancomycin in 29.3 % (36/123), with similar success rates. Recurrence occurred in 16 children (10.8 %), and 3 (2 %) of them presented a further treatment failure. The use of metronidazole was associated with a 5-fold increase in the risk of recurrence [odds ratio (OR) 5.18, 95 % confidence interval (CI) 1.1–23.8, p = 0.03]. Short bowel syndrome was the only underlying condition associated with treatment failure (OR 5.29, 95 % CI 1.17–23.8, p = 0.03). The incidence of pediatric CDI in Italy is low and substantially stable. In this setting, there is a limited risk of recurrence, which mainly concerns children treated with oral metronidazole and those with short bowel syndrome.

Original languageEnglish
Pages (from-to)177-185
JournalEuropean Journal of Clinical Microbiology and Infectious Diseases
Volume36
Issue number1
DOIs
Publication statusPublished - 2017

Fingerprint

Clostridium Infections
Clostridium difficile
Epidemiology
Recurrence
Metronidazole
Italy
Short Bowel Syndrome
Treatment Failure
Odds Ratio
Confidence Intervals
Pediatrics
Community Hospital
Vancomycin
Infection
Hospitalization
Referral and Consultation
Retrospective Studies
Logistic Models
Anti-Bacterial Agents
Incidence

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Clostridium difficile infection in children : epidemiology and risk of recurrence in a low-prevalence country. / Vecchio, A. L O; Lancella, Laura; Tagliabue, Claudia; de Giacomo, C.; Garazzino, Silvia; Mainetti, M.; Cursi, Laura; Borali, E.; de Vita, M. V.; Boccuzzi, Elena; Castellazzi, L.; Esposito, Susanna; Guarino, A.

In: European Journal of Clinical Microbiology and Infectious Diseases, Vol. 36, No. 1, 2017, p. 177-185.

Research output: Contribution to journalArticle

Vecchio, ALO, Lancella, L, Tagliabue, C, de Giacomo, C, Garazzino, S, Mainetti, M, Cursi, L, Borali, E, de Vita, MV, Boccuzzi, E, Castellazzi, L, Esposito, S & Guarino, A 2017, 'Clostridium difficile infection in children: epidemiology and risk of recurrence in a low-prevalence country', European Journal of Clinical Microbiology and Infectious Diseases, vol. 36, no. 1, pp. 177-185. https://doi.org/10.1007/s10096-016-2793-7
Vecchio, A. L O ; Lancella, Laura ; Tagliabue, Claudia ; de Giacomo, C. ; Garazzino, Silvia ; Mainetti, M. ; Cursi, Laura ; Borali, E. ; de Vita, M. V. ; Boccuzzi, Elena ; Castellazzi, L. ; Esposito, Susanna ; Guarino, A. / Clostridium difficile infection in children : epidemiology and risk of recurrence in a low-prevalence country. In: European Journal of Clinical Microbiology and Infectious Diseases. 2017 ; Vol. 36, No. 1. pp. 177-185.
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AU - de Giacomo, C.

AU - Garazzino, Silvia

AU - Mainetti, M.

AU - Cursi, Laura

AU - Borali, E.

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